Formulation, characterization and evaluation of Tramadol Hydrochloride Hydrogel

  • Vipin Kumar Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India
  • Kapil Malviya Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India
  • Lavakesh Kumar Omray Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

Abstract

The challenge in the formulation of novel systems for TDDS is to identify technologies and formulation excipients which simultaneously optimize drug permeation. Our main goal was to design and evaluate a recent alternative for the administration of tramadol HCl. Performed the preformulation study as different evaluation parameters Physiochemical Studies, Solubility Determination, Partition Coefficient, and Preparation of Calibration Curve simultaneously Preparation & Characterization of Hydrogel Formulation Homogeneity, pH Measurement, Drug Content, Viscosity, Spreadability, In-Vitro Permeation, FT-IR Studies. Results revealed that the present investigation, tramadol was successfully incorporated into different gel formulations. Among all gel formulations, tramadol gel (F13) proved to be the formula of choice, showing good characteristics and controlling the drug release for long period of time. Gel formulation F13 could be very promising and innovative topical alternative for pain management and arthritis and play a vital role in drug efficiency. These findings may open new avenues for the treatment through dermal by local application of tailored gel. However, further preclinical and clinical studies are recommended to support its efficiency claims in humans.


Keywords: Tramadol HCl; In-Vitro Permeation; Hydrogel; FT-IR Studies; Characterization

Keywords: Tramadol HCl, In-Vitro Permeation, Hydrogel, FT-IR Studies, Characterization

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Author Biographies

Vipin Kumar, Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

Kapil Malviya, Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

Lavakesh Kumar Omray, Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

Radharamn Institute of Pharmaceutical Sciences Bhopal (M.P) 462044 India

References

1. Ahmed MG, Harish NM, Narayana Charyulu RN, Prabhu P. Formulation of chitosan-based ciprofloxacin and diclofenac film for periodontitis therapy. Tropical Journal of Pharmaceutical Research, 2009; 8 (1):33-41.
2. Ammar HO, Salama HA, Nahhas El, Elmotasem H. Design and Evaluation of Chitosan Films For Transdermal Delivery Of Glimepiride. Current Drug Delivery, 2008; 5:290-298.
3. Amnuaikit C, Ikeuchi I, Ogawara K, Higaki K, Kimura T. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. International Journal of Pharmaceutics, 2005; 289:167–178.
4. Barrett C. Skin penetration, Journal of the Society of Cosmetic Chemist. 1969; 20:487-499.
5. Beppu MM, Vieira RS, Aimoli CG, Santana CC. Crosslinking of chitosan membranes using glutaraldehyde: Effect on ion permeability and water absorption. Journal of Membrane Science, 2007; 301:126–130.
6. Das MK, Bhattacharya A, Ghosal SK. Transdermal delivery of trazodone hydrochloride from acrylic films prepared from aqueous latex. Ind J Pharm Sci., 2006; 68(1):41 -6.
7. Deoda RS, Kumar D and Bhujbal SS. Evidance based Complementary and Alternative Medicine, 2011; 47(1):31- 40.
8. Devi K, Paranjothy KLK. Development and evaluation of free films and transdermal patches of ketorolac tromethamine using polymers and pressure sensitive adhesives. The Eastern Pharmacist, 1998; 41(485):97-100.
9. Frawley D, Ranade S. Ayurveda, Nature's Medicine, Lotous Press, 2004; USA.
10. Goyal R, Mehta A, Shah G. Element of Human Anatomy Physiology & Health Education. B.S. Shah Prakashan, Ahmedabad. 17th Edn., 2007; 78-85 .
11. Gupta SP, Jain SK. Effective and controlled transdermal delivery of metoprolol tartrate. Ind J Pharm Sci., 2005; 67(3):346 -50. 111
12. Gupta V, Yadav SK, Singh D and Gupta N, International Journal of Pharmaceutical and Life Sciemce., 2011; 2(7):952-954.
13. Jain GK, Sharma AK, Agraval SS. Transdermal controlled administration of verapamil enhancement of s kin permeability. Int J Pharm., 1996 130(22):169-77.
14. Jain N, Misra A. Controlled and Novel Drug Delivery, CBS Publishers and Distributors, New Delhi, 2005; 101-106.
15. Jin K, Sang CS. Controlled release of atenolol from the ethylene - vinyl acetate matrix. Int J Pharm., 2004; 273:23 -7.
16. Kaparissides C, Alexandridou S, Kotti K, Chaitidou S. Recent Advances in Novel Drug Delivery Systems, J. of Nanotechnology Online, 2006; 1(3):55-58.
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Kumar V, Malviya K, Omray LK. Formulation, characterization and evaluation of Tramadol Hydrochloride Hydrogel. JDDT [Internet]. 22Oct.2020 [cited 22Oct.2021];10(5-s):177-85. Available from: http://jddtonline.info/index.php/jddt/article/view/4368