Antituberculosis: Synthesis and theoretical study of New Schiff base ligand; 2,2'-{(5-amino-1,3-phenylene) bis[nitrilo(E)methylylidene]}dibenzene-1,4-diol

Synthesis and theoretical study of New Schiff base ligand

  • Kamel Mokhnache Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria
  • Salim Madani Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria
  • Noureddine Charef Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria

Abstract

The ability to breathe and generate adenosine triphosphate is necessary to the persistence, physiology and pathogenesis of Mycobacterium tuberculosis that causes TuB. By doing a theoretical study of a chemical compound, Schiff Base 2,2'-{(5-amino-1,3-phenylene) bis[nitrilo(E)methylylidene]}dibenzene-1,4-diol, where almost all biological activities have been studied theoretically exploiting a computer software PASS (Prediction of Activity Spectra for Substance) for enhancing Computer Aided Drug Designing, as well as studying the class of toxicity in the human body by GUSAR software, which showed biological activity against the tuberculosis epidemic that killed many people, and a protocol was proposed for prepared and study of the properties of this compound.


Keywords: GUSAR software, Synthesis, Schiff base, Tuberculosis, Toxicity, PASS prediction.

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Author Biographies

Kamel Mokhnache, Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria

Department of Process Engineering, Faculty of Technology, University Hassiba Benbouali, Chlef, 02000 Algeria

Salim Madani, Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria

Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and    Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria

Noureddine Charef, Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria

Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and    Life Sciences, University Ferhat Abbas, Setif-1- 19000 Algeria

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Mokhnache K, Madani S, Charef N. Antituberculosis: Synthesis and theoretical study of New Schiff base ligand; 2,2’-{(5-amino-1,3-phenylene) bis[nitrilo(E)methylylidene]}dibenzene-1,4-diol. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):82-5. Available from: http://jddtonline.info/index.php/jddt/article/view/4360