Epidemiological, Clinical, Histological, Serological and Therapeutic Study of Children Celiac Disease in Western Algeria Region

  • Dounia zad EL MEHADJI Laboratory of Molecular Microbiology, Proteomics and Health. Department of Biology, DjillaliLiabes University of Sidibel Abbes, (Ex ITMA), Algeria
  • Khalida ZEMRI Laboratory of Molecular Microbiology, Proteomics and Health. Department of Biology, DjillaliLiabes University of Sidibel Abbes, (Ex ITMA), Algeria
  • Hayet MEHIDA Laboratory of Molecular Microbiology, Proteomics and Health. Department of Biology, DjillaliLiabes University of Sidibel Abbes, (Ex ITMA), Algeria
  • Noria HARIR Laboratory of Molecular Microbiology, Proteomics and Health. Department of Biology, DjillaliLiabes University of Sidibel Abbes, (Ex ITMA), Algeria
  • Djamila YEKROU Departement of medical oncology. Anti-cancer centre of Sidi Bel Abbes. Algeria
  • Karim Bouziane NEDJADI Departement of pediatrics « C »(A.Cabral),CHU of Oran,Algeria
  • Charef LATROCH Departement of pediatrics « C »(A.Cabral),CHU of Oran,Algeria
  • Siheme OUALI Laboratory of Molecular Microbiology, Proteomics and Health. Department of Biology, DjillaliLiabes University of Sidibel Abbes, (Ex ITMA), Algeria
  • Zahira BENAISSA Laboratory of Molecular Microbiology, Proteomics and Health. Department of Biology, DjillaliLiabes University of Sidibel Abbes, (Ex ITMA), Algeria

Abstract

Objectives: To determine the epidemiological, clinical, histological, serological and therapeutic profile of celiac disease in children in Western Algeria region.Methods: 250 patients over a period of three years (2016 - 2019) from the pediatric department of the University Hospital of Oran (West Algeria) were included in our retrospective study.Results: We noticed a female predominance with a sex ratio F/M = 1.57. Symptoms were defined by typical (73.2%) and atypical (26.8%) forms, digestive disorders (47.2%), extra digestive disorders (14.4%). Anemia was noted at 73.6%, and the association with autoimmune diseases at 14.8%. Seropositivity was present in 77.6% of cases and histology revealed partial grade villous atrophy at 54%. We noticed a significant link between the histological grade and the serology (p = 0.001), between age and histological grade (p<10-3), between bone age and body mass index (p = 0.017), between the age of onset of the disease and the age of food diversification (p = 0.030), and with the age of breastfeeding (p = 0.026). In addition, we found an excellent correlation between anti-transglutaminase and anti-endomysium autoantibodies during diagnosis and under diet (p<10-3), and between serology during diagnosis and serology under diet (p = 0.002)Conclusion: Celiac disease (CD) of children in western Algeria is characterized by a variety of clinical symptoms. The gluten-free diet remains the only therapy for these affected children.


Keywords: celiac disease, children, epidemiology, serology, histology, associated diseases, treatment.

Keywords: celiac disease, children, epidemiology, serology, histology, associated diseases, treatment

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EL MEHADJI D zad, ZEMRI K, MEHIDA H, HARIR N, YEKROU D, NEDJADI KB, LATROCH C, OUALI S, BENAISSA Z. Epidemiological, Clinical, Histological, Serological and Therapeutic Study of Children Celiac Disease in Western Algeria Region. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):6-0. Available from: http://jddtonline.info/index.php/jddt/article/view/4344