Systemic Lupus Erythematosus in Algerian Men: Clinical-Biological and Evolutionary Analysis of 19 Algerian Men

  • Naima Rania Belmokhtar Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria
  • Khalida Zemri Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria
  • Khedoudja Kanoun Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria
  • Noria Harir Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria
  • B.M. Bachaoui Department of Internal Medicine-Diabetes, Etablissement Hospitalier Universitaire d'ORAN 1 November 1954, Algeria. Address: BP N° 4166 Ibn Rochd. Oran 31000, Algeria
  • Sid Tadj Hebri Department Internal Medicine, University Hospital Centre CHU Dr HASSANI Abdelkader. Sidi Bel Abbes, Algeria. Address: Rue Belahcen Mourad, Sidi Bel Abbes 22000, Algeria

Abstract

Objectives: the aim of our study was to precise the epidemiological, clinicobiological, immunological, and evolutionary profile of systemic lupus erythematosus in Algerian men.


Methods: A retrospective multicenter study was carried out on 19 Algerian male lupus patients, diagnosed according to the ACR and SLICC criteria and followed between 2006 and 2019 on a total of 203 cases of systemic lupus erythematosus in western Algeria.


Results: 203 SLE patients were included, 19 men (9.4%) and 184 women (90.6%) with F/ M sex ratio of 9.68 / 1. The mean age at diagnosis was 33 ± 9.49 years. The most frequent clinical manifestations were joint involvement (84.2%), cutaneous (68.4%) and hematological disorder (63.2%). 15.8% had lupus nephropathies with the predominance of class IV; Raynaud's syndrome and neuropsychiatric involvement were found in 26.3%. Comparison of these results with those of 184 lupus women showed a significant frequency of mucosal ulcer (p=0.000011) and neuropsychiatric damage in men (p=0.011), while alopecia in women (p=0.021). As well, hypocomplementemia (p=0.0004), anti-Sm antibodies (p=0.053) and anti Ribosome (p=0.028) were more frequent in men; while anti-SSA (p=0.003) and anti-SSB (p=0.011) antibodies were more frequent in women. Survival of lupus men was equal to 100% throughout the studied period.


Conclusion: Male lupus is rare. The Algerian man suffers from SLE in a less severe form compared to other data in the literature, which is manifested by a lower frequency of organ damage and mortality.


Keywords: Male lupus, epidemiology, clinical polymorphism, evolutionary profile, western Algeria.

Keywords: Male lupus, epidemiology, clinical polymorphism, evolutionary profile, western Algeria

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Author Biographies

Naima Rania Belmokhtar, Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Khalida Zemri, Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Khedoudja Kanoun, Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Noria Harir, Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

Molecular Microbiology, Proteomics and Health Laboratory, Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés, Algeria. Address: Rectorat Ex ITMA, Sidi Bel Abbes, 22000 BP.89 sidi Bel Abbes, Algeria

B.M. Bachaoui, Department of Internal Medicine-Diabetes, Etablissement Hospitalier Universitaire d'ORAN 1 November 1954, Algeria. Address: BP N° 4166 Ibn Rochd. Oran 31000, Algeria

Department of Internal Medicine-Diabetes, Etablissement Hospitalier Universitaire d'ORAN 1 November 1954, Algeria. Address: BP N° 4166 Ibn Rochd. Oran 31000, Algeria

Sid Tadj Hebri, Department Internal Medicine, University Hospital Centre CHU Dr HASSANI Abdelkader. Sidi Bel Abbes, Algeria. Address: Rue Belahcen Mourad, Sidi Bel Abbes 22000, Algeria

Department Internal Medicine, University Hospital Centre CHU Dr HASSANI Abdelkader. Sidi Bel Abbes, Algeria. Address: Rue Belahcen Mourad, Sidi Bel Abbes 22000, Algeria

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Belmokhtar NR, Zemri K, Kanoun K, Harir N, Bachaoui B, Hebri ST. Systemic Lupus Erythematosus in Algerian Men: Clinical-Biological and Evolutionary Analysis of 19 Algerian Men. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):18-3. Available from: http://jddtonline.info/index.php/jddt/article/view/4334