BIOADHESIVE MULTIPARTICULATE (MICROSPHERS) DRUG DELIVERY SYSTEM: A REVIEW

  • Ravindra B Borade S. N. D. College of Pharmacy, Yeola, Dist Nasik, Maharashtra, India.
  • Yogesh Y Mahajan S. N. D. College of Pharmacy, Yeola, Dist Nasik, Maharashtra, India.
  • Nilesh P Jadhav S. N. D. College of Pharmacy, Yeola, Dist Nasik, Maharashtra, India.
  • Jaiprakash V Kokane S. N. D. College of Pharmacy, Yeola, Dist Nasik, Maharashtra, India.
  • Md. Rageeb Md. Usman Assistant Professor, Department of Pharmacognosy, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India.
  • Mrugendra B Potdar Assistant Professor, Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Abstract

The concept of controlled drug delivery has been traditionally used to obtain specific release rates or targeting of active ingredients. The phenomenon of bioadhesion has been studied extensively in the last decade and applied to improve the performance of these drug delivery systems. Recent advances in polymer science and drug carrier technologies have promulgated the development of novel drug carriers such as bioadhesive microspheres that have boosted the use of “bioadhesion†in drug delivery. This article presents the spectrum of potential applications of bioadhesive microspheres in controlled drug delivery ranging from the small molecules, to peptides, and to the macromolecular drugs such as proteins, oligonucleotides and even DNA. The development of mucus or cell-specific bioadhesive polymers and the concepts of cytoadhesion and bioinvasion provide unprecedented opportunities for targeting drugs to specific cells or intracellular compartments. Developments in the techniques for in vitro and in vivo evaluation of bioadhesive microspheres have also been discussed.

Keywords: - Bioadhesion, Bioadhesive Microspheres, Development, Polymers.

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How to Cite
Borade, R., Mahajan, Y., Jadhav, N., Kokane, J., Usman, M. R., & Potdar, M. (2013). BIOADHESIVE MULTIPARTICULATE (MICROSPHERS) DRUG DELIVERY SYSTEM: A REVIEW. Journal of Drug Delivery and Therapeutics, 3(2). https://doi.org/10.22270/jddt.v3i2.433