Synthesis and Pharmacological Evaluation of 2-(4-(3 (Substituted Phenyl) Acryloyl) Phenoxy)-N, N Diphenylacetamides

  • Rohit Kumar Research Scholar, School of Pharmaceutical Sciences, IFTM University, Moradabad (UP) India
  • Sushil Kumar Professor, School of Pharmaceutical Sciences, IFTM University, Moradabad (UP) India
  • Mohammad Asif Khan Assistant Professor, Future Institute of Pharmacy, Future University, Bareilly (UP) India

Abstract

Recently a series of Schiff bases of diphenylamine derivatives have been synthesized and evaluated in vitro for their antibacterial activity against pathogenic both Gram-positive bacteria B. subtitles and Gram-negative bacteria E. coli using ciprofloxacin as standard drug at conc. of 50 μg/ml and 100 μg/ml. Literature review revels that chalcones possesses various biological activities like antimicrobial, antiviral, anti-inflammatory, anticancer and sedative etc. Therefore the present study was designed on synthesis and pharmacological evaluation of 2-(4-(3 (Substituted Phenyl) Acryloyl) Phenoxy)-N, N Diphenylacetamides. Target compound was synthesized by reaction of chloroacetylchloride with diphenylamine to afford 2-chloro-N, N-diphenylacetamide which further by reaction with substituted Chalcones and characterized following recrystallization and evaluated for anti-microbial potential through cup-diffusion method. In results, the target compounds were tested for activity against B. Subtilis, E.Coli and C. albicans. The chalcones having the lipophilic 4-chloro group (RKCT2) showed the greatest antimicrobial activity (zone of inhibition 20 & 22 mm against. B. subtilis, E. Coli, C. Albicans respectively. It suggests further researchers to go through anti-microbial evaluations against a more varieties of bacteria and fungi.


Keywords: Schiff bases of diphenylamine derivatives, antibacterial activity, Gram-positive bacteria, 2-(4-(3 (Substituted Phenyl) Acryloyl) Phenoxy)-N, N Diphenylacetamides

Keywords: Schiff bases of diphenylamine derivatives, antibacterial activity, Gram-positive bacteria, 2-(4-(3 (Substituted Phenyl) Acryloyl) Phenoxy)-N, N Diphenylacetamides

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Author Biographies

Rohit Kumar, Research Scholar, School of Pharmaceutical Sciences, IFTM University, Moradabad (UP) India

Research Scholar, School of Pharmaceutical Sciences, IFTM University, Moradabad (UP) India

Sushil Kumar, Professor, School of Pharmaceutical Sciences, IFTM University, Moradabad (UP) India

Professor, School of Pharmaceutical Sciences, IFTM University, Moradabad (UP) India

Mohammad Asif Khan, Assistant Professor, Future Institute of Pharmacy, Future University, Bareilly (UP) India

Assistant Professor, Future Institute of Pharmacy, Future University, Bareilly (UP) India

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Kumar R, Kumar S, Khan MA. Synthesis and Pharmacological Evaluation of 2-(4-(3 (Substituted Phenyl) Acryloyl) Phenoxy)-N, N Diphenylacetamides. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):274-92. Available from: http://jddtonline.info/index.php/jddt/article/view/4326