N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment

  • Filia Yuniza Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia
  • Eddy Mart Salim Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia
  • Nova Kurniati Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia
  • Harun Hudari Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia
  • Erial Bahar Department of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia
  • Agustian Dwi Putra Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia
  • Sri Sulpha Siregar Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia
  • Guntur Baruara Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Abstract

Aims: to determine the effect of NAC administration on hematological abnormalities in HIV/AIDS patients who are undergoing ARV treatment.


Method: This was a pilot study using a double blind randomized clinical trial. A total of 32 subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely placebo and NAC. Subjects in the NAC group were given NAC at a dose of 3x200 mg/day, while the placebo group was given lactose at a dose of 3x200 mg/day. Each group was given treatment for 12 weeks. Before and after treatment, subjects were examined for hematologic parameters.


Results:  Most of subjects had normal hematological features. NAC administration did not have a significant effect on the mean levels of Hb, Ht, number of erythrocytes, leukocytes and platelets (p> 0.05). However, NAC administration can reduce the degree of anemia and improve the condition of thrombocytopenia, leukopenia and lymphopenia.


Conclusion: NAC administration can reduce hematological abnormalities HIV/AIDS patients undergoing ARV treatment.


Keywords: ARV, Hematological abnormalities, HIV/AIDS, NAC.

Keywords: ARV, Hematological abnormalities, HIV/AIDS, NAC

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Author Biographies

Filia Yuniza, Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Eddy Mart Salim, Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Nova Kurniati, Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Harun Hudari, Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Erial Bahar, Department of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Department of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Agustian Dwi Putra, Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Department of Internal Medicine, Muhammad Hoesin Central Hospital, Indonesia

Sri Sulpha Siregar, Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Guntur Baruara, Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

Magister of Biomedical Science, Medical Faculty, Universitas Sriwijaya, Indonesia

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Yuniza F, Salim E, Kurniati N, Hudari H, Bahar E, Putra A, Siregar S, Baruara G. N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment. JDDT [Internet]. 20Aug.2020 [cited 23Apr.2021];10(4-s):197-00. Available from: http://jddtonline.info/index.php/jddt/article/view/4319