Formulation and evaluation of gas powered systems of cefdinir tablets for controlled release
The present work is aimed to formulate Cefdinir floating tablets using different hydrophilic and hydrophobic polymers like HPMC, Ethyl cellulose, Xanthum gum, guar gum and gas generating agent Sodium bicarbonate. The develop gastro retentive dosage form thatcould retain the agent namely Cefdinir in the stomach for longer periods of time delivering the drug to the site of action, i.e., stomach. HPMC is used as a swelling agent, Guar gum and Xanthum gum is used as binding agent. Ethyl cellulose is used as matrix form agent. PVP is used as a suspending agent. Sodium bicarbonate is used as a gas forming agent. MCC is used as a disintergrant and diluent. Magnesium stearate is used as a lubricant. The prepared Cefdinir tablets will be evaluated for drug content, entrapment efficiency, post compression studies, In-vitro buoyancy studies, swelling index studies, in-vitro dissolution studies, release kinetics, stability studies.All these parameters were found to be within the pharmacopoeial limits. Formulation F5 was selected for drug release and stability study on the basis of appropriate results of post compression study.In vitro dissolution study was carried out and showed controlled release pattern.
Keywords: Gas Powered Systems, Cefdinir, Controlled release, Floating drug delivery.
2. Mathur P, Saroha K, Syan N, Verma S, Kumar V. Floating drug delivery system: An innovative acceptable approachin gastroretentive drug delivery. Arch Appl Sci Res. 2010; 2(2):257-270.
3. Desai S, Bolton SA. A floating controlled release drug delivery system: In vitro-In vivo evaluation. Pharm Res 1993; 10(9):1321-1325.
4. Amrutkar PP, Chaudhari PD, Patil SB. Design and in vitro evaluation of multiparticulate floating drug delivery system of zolpidemtartarate. Colloid Surface B., 2012; 89:182-187.
5. Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford; ISBN 326 9780191039621, 2009, pp. 56.
6. Ponchel G, Irache J-M. Specific and non-specific bioadhesive participate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliver Rev 1998; 34:191-219.
7. Deshpande AA, Shah NH, Rhodes CT, Malick W. Development of a novel controlled release system for gastric retention. Pharm. Res., 1997; 14:815-819.
8. Davis SS, Stockwell AF, Taylor MJ et al. The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm. Res., 1997; 3: 208-213.
9. Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003; 90:143-162.
10. Kedzierewicz F, Thouvenot P, Lemut J, Etienne A, Hoffman M, Maincent P. Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy. J Control Release. 1999; 58:195-205.
11. Groning R, Heun G. Oral dosage forms with controlled gastrointestinal transit. Drug Dev Ind Pharm. 1984; 10:527-539.
12. Chawla G, Gupta P, Koradia V, Bansal AK. Gastroretention a means to address intestinal drug absorption. Pharm Technol 2003; 27:50-68.
13. Singh BN and Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J. Control. Release. 2000; 63:235-239.
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