Formulation and evaluation of gas powered systems of cefdinir tablets for controlled release

  • Manoj R. Chincholikar NRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar, Raisen Rd, opposite Patel Nagar, Bhopal, Madhya Pradesh 462021, India
  • Jagdish Rathi NRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar, Raisen Rd, opposite Patel Nagar, Bhopal, Madhya Pradesh 462021, India

Abstract

The  present  work  is  aimed  to  formulate  Cefdinir  floating  tablets  using different  hydrophilic  and  hydrophobic  polymers  like  HPMC,  Ethyl  cellulose, Xanthum gum, guar gum and gas generating agent Sodium bicarbonate. The develop gastro retentive dosage form thatcould  retain  the  agent  namely  Cefdinir  in  the  stomach  for  longer periods of time delivering the drug to the site of action, i.e., stomach. HPMC  is  used  as  a  swelling  agent,  Guar  gum  and  Xanthum  gum  is used as binding agent. Ethyl cellulose is used as matrix form agent.  PVP is used as a suspending agent. Sodium bicarbonate is used as a gas forming agent. MCC is used as a disintergrant and diluent. Magnesium stearate is used as a lubricant. The  prepared  Cefdinir  tablets  will  be  evaluated  for  drug  content,  entrapment efficiency, post compression studies, In-vitro buoyancy studies, swelling index studies, in-vitro dissolution studies, release kinetics, stability studies.All these parameters were found to be within the pharmacopoeial limits. Formulation F5 was selected for drug release and stability study on the basis of appropriate results of post compression study.In vitro dissolution study was carried out and showed controlled release pattern.


Keywords: Gas Powered Systems, Cefdinir, Controlled release, Floating drug delivery.

Keywords: Gas Powered Systems, Cefdinir, Controlled release, Floating drug delivery

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Author Biographies

Manoj R. Chincholikar, NRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar, Raisen Rd, opposite Patel Nagar, Bhopal, Madhya Pradesh 462021, India

NRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar, Raisen Rd, opposite Patel Nagar, Bhopal, Madhya Pradesh 462021, India

Jagdish Rathi, NRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar, Raisen Rd, opposite Patel Nagar, Bhopal, Madhya Pradesh 462021, India

NRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar, Raisen Rd, opposite Patel Nagar, Bhopal, Madhya Pradesh 462021, India

References

1. Kaushik A, Dwivedi A, Kothari P, Govil A. Floating drug delivery system a significant tool for stomach specific release of cardiovascular drugs. Int. J. Drug Dev. Res., 2012; 4(4):116-129.
2. Mathur P, Saroha K, Syan N, Verma S, Kumar V. Floating drug delivery system: An innovative acceptable approachin gastroretentive drug delivery. Arch Appl Sci Res. 2010; 2(2):257-270.
3. Desai S, Bolton SA. A floating controlled release drug delivery system: In vitro-In vivo evaluation. Pharm Res 1993; 10(9):1321-1325.
4. Amrutkar PP, Chaudhari PD, Patil SB. Design and in vitro evaluation of multiparticulate floating drug delivery system of zolpidemtartarate. Colloid Surface B., 2012; 89:182-187.
5. Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford; ISBN 326 9780191039621, 2009, pp. 56.
6. Ponchel G, Irache J-M. Specific and non-specific bioadhesive participate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliver Rev 1998; 34:191-219.
7. Deshpande AA, Shah NH, Rhodes CT, Malick W. Development of a novel controlled release system for gastric retention. Pharm. Res., 1997; 14:815-819.
8. Davis SS, Stockwell AF, Taylor MJ et al. The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm. Res., 1997; 3: 208-213.
9. Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003; 90:143-162.
10. Kedzierewicz F, Thouvenot P, Lemut J, Etienne A, Hoffman M, Maincent P. Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy. J Control Release. 1999; 58:195-205.
11. Groning R, Heun G. Oral dosage forms with controlled gastrointestinal transit. Drug Dev Ind Pharm. 1984; 10:527-539.
12. Chawla G, Gupta P, Koradia V, Bansal AK. Gastroretention a means to address intestinal drug absorption. Pharm Technol 2003; 27:50-68.
13. Singh BN and Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J. Control. Release. 2000; 63:235-239.
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Chincholikar MR, Rathi J. Formulation and evaluation of gas powered systems of cefdinir tablets for controlled release. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):182-7. Available from: http://jddtonline.info/index.php/jddt/article/view/4310