Lipid ratios as a predictive marker of Subclinical Atherosclerosis inflammation among Type 1 Diabetic patients with Thyroid Dysfunction

  • Walid Hassene HAMRI Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria
  • Mustapha DIAF Department of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University of Sidi-Bel-Abbès, Algeria.
  • Noria HARIR Laboratory of Molecular Microbiology, Proteomics and Health, Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria
  • Mohamed HADJ HABIB Department of Medecine, Faculty of Medicine, Djillali Liabes University of Sidi-bel-Abbes, Algeria

Abstract

Background and Objectives: Epidemiological inquiries on the subclinical atherosclerotic disease in type 1 diabetes associated with autoimmune thyroid disease are scarce. Our aim was to evaluate the risk of developing atherosclerosis via lipid ratios by comparing two groups of patients according to their TSH (Thyroid-stimulating hormone) status.


Methods: A retrospective study including 190 patients (13-74 years) with confirmed type 1 diabetes divided into the following groups (patients with serum TSH < 2.5 μIU/mL vs. patients with serum TSH ≥ 2.5 μIU/mL). Autoimmune thyroid disease was classified according to clinical, biological, and follow up data.


Results: Our study showed a slight predominance of females (50.50%), with an average age of 29.25±11.39 years. The prevalence of hypothyroidism was 14.7%, hyperthyroidism 6.3%, and anti-TPO 16.31%. Significant differences were observed between lipid profiles such as HDL and TG (p= 0.008; p=0.04, respectively). The results showed that the 3rd (OR= 2.28 [0.72-7.20]; p=0.15) and the fourth quartiles (OR= 1.9 [0.61-5.83]; p=0.26) of TC/HDL ratio were higher in patients with serum TSH ≥ 2.5 μIU/mL group. Similarly, we noticed higher concordant values on the last quartile (4th) of LDL/HDL ratio with p values of 0.06 as well as the two quartiles (2ndand 4th) of TG/HDL ratio with p values of 0.03 and 0.04, respectively. In both groups, lipid ratios were slightly higher in males compared to females’ patients.


Conclusion: The risk of atherosclerosis was higher in patients with elevated TSH concentrations. Therefore, early detection of thyroid dysfunction and associated dyslipidemia is essential for effective prevention of premature cardiovascular morbidity and mortality.


Keywords: Subclinical atherosclerotic disease, autoimmune thyroid disease, TSH, type 1 diabetes

Keywords: Subclinical atherosclerotic disease, autoimmune thyroid disease, TSH, type 1 diabetes

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Author Biographies

Walid Hassene HAMRI, Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria

Laboratory of Molecular Microbiology, Proteomics and Health, Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria

Mustapha DIAF, Department of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University of Sidi-Bel-Abbès, Algeria.

Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria

Noria HARIR, Laboratory of Molecular Microbiology, Proteomics and Health, Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria

Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-bel-Abbes, Algeria

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HAMRI WH, DIAF M, HARIR N, HADJ HABIB M. Lipid ratios as a predictive marker of Subclinical Atherosclerosis inflammation among Type 1 Diabetic patients with Thyroid Dysfunction. JDDT [Internet]. 15Aug.2020 [cited 23Apr.2021];10(4-s):112-9. Available from: http://jddtonline.info/index.php/jddt/article/view/4307