A Laconic Review on Extraction, Biological Activities of Herbal Formulations of Berberine: A Traditional Drug

  • Shivi Sondhi Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
  • Navdeep Singh Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
  • Kamya Goyal Department of Pharmaceutical Chemistry and Analysis, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
  • Shammy Jindal Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Abstract

Herbal formulation dosage form consists of one or more herbs processed in specified quantities to provide specific nutritional, cosmetic benefits use to diagnose the disease. Herbal formulations contain an active substance and preparation in combination of one or more herbal compounds. Berberis aristata is one of herbs of an ancient Ayurveda medicine and different properties along with various treatment of illness. Berberine, is a type of alkaloid which is quarternary protoberberine, is one of the known bioactive compounds scattered extensively in a number of clinically significant medicinal plants such as Hydrastis canadensis L., Phellodendron amurense R. ,Coptis japonica M.,  and  Berberine containing plants have been used in traditional and folk medicine around the globe for centuries. It has been used for a, anti-pyretic diarrhea, bitter tonic, and eye infections. In the past three eras, Berberine has been studied intensively in over thousands cases because of its therapeutics, physicochemical effects, pharmacological, and physiological effects such as cardiovascular, anti-inflammatory, anti leshmanial, and  anti- secretory, effects. Berberine act as a phytoconstituents in formulations and available in ayurveda, allopathy, and homeopathy medicines. With this review, we will evaluate the various traditional and medicinal use of Berberine and their isolation and extraction procedure. We will also review the potential of this plant as various dosage forms for the treatment of various diseases.


Keywords: Berberine; Extraction Method; Isolation method; Skin problems

Keywords: Berberine, Extraction Method, Isolation method, Skin problems

Downloads

Download data is not yet available.

Author Biographies

Shivi Sondhi, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Navdeep Singh, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Kamya Goyal, Department of Pharmaceutical Chemistry and Analysis, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Department of Pharmaceutical Chemistry and Analysis, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Shammy Jindal, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Research scholar, Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida 201303, India

References

1. Jindal S, Awasthi R, Singhare D, Kulkarni GT, “Topical delivery of Tacrolimus using liposome containing gel: An emerging and synergistic approach in management of psoriasis” Medical Hypotheses, 2020:109838.
2. Seethapathy GS, Raclariu-Manolica AC, Anmarkrud JA, Wangensteen H, De Boer HJ. DNA metabarcoding authentication of Ayurvedic herbal products on the European market raises concerns of quality and fidelity. Frontiers in plant science. 2019; 10:68.
3. Devarbhavi H, “Aurvedic and herbal medicine-induced liver injury: It is time to wake up and take notice” springer, 2018;5-7
4. Cui H, Cai Y, Wang L, Jia B, Li J, Zhao S, Chu X, Lin J, Zhang X, Bian Y, Zhuang P. Berberine regulates Treg/Th17 balance to treat ulcerative colitis through modulating the gut microbiota in the colon. Frontiers in pharmacology. 2018; 31(9):571.
5. Cao M, Wang P, Sun C, He W, Wang F. Amelioration of IFN-γ and TNF-α-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway. PloS one. 2013; 8(5):e61944.
6. Karimov A, “Berberis alkaloids” Chemistry of natural compounds, 1993; 29(4):415-38.
7. Birdsall TC, “Berberine: Therapeutic potential of alkaloid found in several medicinal plants” Altern. Med. Rev, 1997; 2:94-103.
8. Gupta A, “Vitamin D deficiency in India: prevalence, causalities and interventions” Nutrients, 2014; 6(2):729-75.
9. Tandon R, Khanna RD, Dorababu M, Goel RK. Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma. Indian Journal of Physiology and Pharmacology. 2004 24; 48(1):115-8.
10. Singh A, Duggal S, Singh H, Singh J, Katekhaye S. Withanolides: Phytoconstituents with significant pharmacological activities. International Journal of Green Pharmacy (IJGP). 2010; 4(4).
11. Amritpal S, Sanjiv D, Navpreet K, Jaswinder S, “Berberine: alkaloid with wide spectrum of pharmacological activities” Journal of Natural Products (India), 2010; 3:64-75.
12. Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2010; 24(3):317-24.
13. Marek R, Sečkářová P, Hulová D, Marek J, Dostál J, Sklenář V. Palmatine and berberine isolation artifacts. Journal of natural products. 2003; 66(4):481-6.
14. Grycova L, Dostál J, Marek R, “Quaternary protoberberine alkaloids” Phytochemistry, 2007; 68(2):150-75.
15. Babu NH, Thriveni HN, Vasudeva R, “Influence of drying methods and extraction procedures on the recovery of berberine content in Coscinium fenestratum” J. Nat. Prod. Plant Resour, 2012; 2:540-4.
16. Teng H, Choi Y. Optimum extraction of bioactive alkaloid compounds from Rhizome coptidis (Coptis chinensis Franch.) using response surface methodology. Solvent Extraction Research and Development, Japan. 2013; 20:91-104.
17. Mokgadi J, Turner C, Torto N. Pressurized hot water extraction of alkaloids in Goldenseal. American Journal of Analytical Chemistry. 2013;2013.
18. Rojsanga P, Gritsanapan W. Variation of berberine content in coscinium fenestratum stem in Thailand Market. The Mahidol University Journal of Pharmaceutical Sciences. 2005; 32(3-4):66-70.
19. Rojsanga P, Gritsanapan W, Suntornsuk L. Determination of berberine content in the stem extracts of Coscinium fenestratum by TLC densitometry. Medical Principles and Practice. 2006; 15(5):373-8.
20. Shigwan H, Saklani A, Hamrapurkar PD, Mane T, Bhatt P. HPLC Method Development and Validation for Quantification of Berberine from Berberis aristata and Berberis tinctoria. International Journal of Applied Science and Engineering. 2013; 11(2):203-11.
21. Alupului A, Calinescu I, Lavric V, “Ultrasonic vs. microwave extraction intensification of active principles from medicinal plants” InAIDIC conference series, 2009; 10(9):1-8.
22. Chang Y, “Ultrasonic-assisted extraction of berberine in ionic liquid pharm” Eng. 2014; 33:1-4.
23. Xu K, He G, Qin J, Cheng X, He H, Zhang D, Peng W. High-efficient extraction of principal medicinal components from fresh Phellodendron bark (cortex phellodendri). Saudi journal of biological sciences. 2018; 25(4):811-5.
24. Xi J. Ultrahigh pressure extraction of bioactive compounds from plants—a review. Critical reviews in food science and nutrition. 2017; 57(6):1097-106.
25. Liao G, Liu J, He S, Chen J, Zhang Z, “Optimization for ultrahigh pressure extraction of berberine from Cortex Phellodendri by central composite design-response surface methodology” Journal of medicinal plants research, 2012; 6(23):3963-70.
26. Mustafa, A. and Turner, C., Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review. Analytica chimica acta, 2011; 703(1):8-18.
27. Samal PK. HPTLC analysis of berberine in Argemone mexicana, L. Journal of global trends in pharmaceutical sciences. 2013; 4(2):1073-6.
28. Singh R, Ray P, Das A, Sharma M. Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms. Journal of antimicrobial chemotherapy. 2010; 65(9):1955-8.
29. Liu B, Li W, Chang Y, Dong W, Ni L. Extraction of berberine from rhizome of Coptis chinensis Franch using supercritical fluid extraction. Journal of Pharmaceutical and Biomedical Analysis. 2006; 41(3):1056-60.
30. Liu S, Chen Y, Gu L, Li Y, Wang B, Hao J, Zhu H, Li H, Yang S, Kitanaka S. Effects of ultrahigh pressure extraction conditions on yields of berberine and palmatine from cortex Phellodendri amurensis. Analytical Methods. 2013; 5(17):4506-12.
31. Arawwawala LD, Wickramaarachchi WA, “Berberine content in Coscinium fenestratum (Gaertn.) colebr grown in Sri Lanka” Pharmacologia, 2012; 3(12):679-82.
32. Akowuah GA, Okechukwu PN, Chiam NC, “Evaluation of HPLC and spectrophotometric methods for analysis of bioactive constituent berberine in stem extracts of Coscinium fenestratum” Acta Chromatographica, 2014; 26(2):243-54.
33. Rojsanga P, Sukhthankar M, Krisanapun C, Gritsanapan W, Buripakdi Lawson D, Baek SJ. In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells. experimental and therapeutic medicine. 2010; 1(1):181-6.
34. Patel MC. Isolation of berberine from Berberis aristata by an acid dye method and optimization of parameters. Int. J. Pharm. Sci. Rev. Res. 2013; 20(2):187-9.
35. Liu M, Yin X, Ulin-Avila E, Geng B, Zentgraf T, Ju L, Wang F, Zhang X. A graphene-based broadband optical modulator. Nature. 2011; 474(7349):64-7.
36. Wang Z, Bapst V, Heess N, Mnih V, Munos R, Kavukcuoglu K, de Freitas N. Sample efficient actor-critic with experience replay. arXiv preprint arXiv:1611.01224. 2016; 3.
37. Xu B, Li P, Zhang G. Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography–mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats. Journal of Chromatography B. 2015; 15(988):33-44.
38. Yang L, Meng X, Yu X, Kuang H. Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC–ESI–MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats. Journal of pharmaceutical and biomedical analysis. 2017; 134:43-52.
39. Pfoze NL, Myrboh B, Kumar Y, Rohman MR. Isolation of protoberberine alkaloids from stem bark of Mahonia manipurensis Takeda using RP-HPLC. Journal of Medicinal Plants. 2014; 2(2):48-57.
40. Satija R, Farrell JA, Gennert D, Schier AF, Regev A. Spatial reconstruction of single-cell gene expression data. Nature biotechnology. 2015; 33(5):495-502.
41. Joshi H, Kanaki N, “Quantitative analysis of berberine in an ayurvedic formulation-Rasayana churna by UV spectrophotometry” J. Pharm. Sci. Biosci. Res, 2013; 3:32-4.
42. Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha LY. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. African Journal of Traditional, Complementary and Alternative Medicines. 2011; 8(1).
43. Du JX, Wang M, “Capillary Electrophoresis Determination of Berberine in Pharmaceuticals with End‐Column Electrochemi-luminescence Detection” Journal of the Chinese Chemical Society, 2010; 57(4A):696-700.
44. Minaiyan M, Ghannadi A, Mahzouni P, Jaffari-Shirazi E. Comparative study of Berberis vulgaris fruit extract and berberine chloride effects on acetic acid-induced colitis in rats. Iranian journal of pharmaceutical research: IJPR. 2011; 10(1):97.
45. Ransohoff RM, Hafler DA, Lucchinetti CF. Multiple sclerosis—a quiet revolution. Nature Reviews Neurology. 2015; 11(3):134.
46. Liu X, Zhang X, Ye L, Yuan H. Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. Biomedicine & Pharmacotherapy. 2016; 1(79):222-30.
47. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE, “Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases” Physiological reviews, 2014; 94(2):329-54.
48. Pilch W, Szygula Z, Tyka AK, Palka T, Tyka A, Cison T, Pilch P, Teleglow A. Disturbances in pro-oxidant-antioxidant balance after passive body overheating and after exercise in elevated ambient temperatures in athletes and untrained men. PloS one. 2014; 9(1):e85320.
49. Ho PL, Chow KH, Lai EL, Lo WU, Yeung MK, Chan J, Chan PY, Yuen KY. Extensive dissemination of CTX-M-producing Escherichia coli with multidrug resistance to ‘critically important’antibiotics among food animals in Hong Kong, 2008–10. Journal of antimicrobial chemotherapy. 2011; 66(4):765-8.
50. Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. Oxidative stress, prooxidants, and antioxidants: the interplay. BioMed research international. 2014.
51. Shirwaikar A, Shirwaikar A, Rajendran K, Punitha IS. In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine. Biological and Pharmaceutical Bulletin. 2006; 29(9):1906-10.
52. Liu L, Liu J, Huang Z, Yu X, Zhang X, Dou D, Huang Y. Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats. Biochemical and Biophysical Research Communications. 2015; 458(4):796-801.
53. Zhu L, Zhang D, Zhu H, Zhu J, Weng S, Dong L, Liu T, Hu Y, Shen X. Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe−/− mice. Atherosclerosis. 2018; 268:117-26.
54. Zhao G, Cawood PA. Precambrian geology of China. Precambrian Research. 2012; 222:13-54.
55. Domitrović R, Jakovac H, Blagojević G, “Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl4-intoxicated mice” Toxicology, 2011; 280(1-2):33-43.
56. Mehrzadi S, Fatemi I, Esmaeilizadeh M, Ghaznavi H, Kalantar H, Goudarzi M. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomedicine & Pharmacotherapy. 2018; 97:233-9.
57. Neag MA, Mocan A, Echeverría J, Pop RM, Bocsan CI, Crişan G, Buzoianu AD. Berberine: Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders. Frontiers in pharmacology. 2018; 21(9):557.
Statistics
3 Views | 4 Downloads
How to Cite
1.
Sondhi S, Singh N, Goyal K, Jindal S. A Laconic Review on Extraction, Biological Activities of Herbal Formulations of Berberine: A Traditional Drug. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):345-57. Available from: http://jddtonline.info/index.php/jddt/article/view/4300