A Review on Pharmacological Aspects of Pyrimidine Derivatives

  • Vishal Verma U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India
  • Chandra Prakash Joshi U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India
  • Alka Agarwal U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India
  • Sakshi Soni Pacific College of Pharmacy Udaipur, Rajasthan, India
  • Udichi Kataria Geetanjali Institute of Pharmacy Udaipur Rajasthan, India

Abstract

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogens at positions 1 and 3 in the ring. Pyrimidines are typically synthesized by the “Principal Synthesis” involving cyclization of beta-dicarbonyl compounds with N-C-N compounds. Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidiones, and guanidines to give 2-aminopyrimidines are typical. Pyrimidines can be prepared via the biginelli reaction. Many other methods rely on condensation of carbonyls with diamines for instance the synthesis of 2-Thio-6-methyluracil from thiouria and ethyl acetoacetate or the synthesis of 4-methylpyrimidine with 4, 4-dimethoxy-2-butanone and formamide. Pyrimidine derivatives show antimicrobial activity, anticancer activity, anti-inflammatory activity, antidiabetic, and analgesic activity.1.


Keywords: Pyrimidine derivatives, Synthesis, derivatives and pharmacological activities.

Keywords: Pyrimidine derivatives, Synthesis, derivatives and pharmacological activities

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Author Biographies

Vishal Verma, U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India

U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India

Chandra Prakash Joshi, U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India

U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India

Alka Agarwal, U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India

U S Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh, (Raj.), India

Sakshi Soni, Pacific College of Pharmacy Udaipur, Rajasthan, India

Pacific College of Pharmacy Udaipur, Rajasthan, India

Udichi Kataria, Geetanjali Institute of Pharmacy Udaipur Rajasthan, India

Geetanjali Institute of Pharmacy Udaipur Rajasthan, India

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Verma V, Joshi CP, Agarwal A, Soni S, Kataria U. A Review on Pharmacological Aspects of Pyrimidine Derivatives. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):358-61. Available from: http://jddtonline.info/index.php/jddt/article/view/4295