A Review on Antimalarial 1,2,4-Trioxane Derivatives

  • Amit Choudhary Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India
  • Manish Sinha Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India
  • Arti Devi Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India
  • Shammy Jindal Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Distt.- Kangra, H.P., India
  • Kamya Goyal Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Abstract

Malaria in recent years becomes a major health hitch globally due to the surfacing of multidrug-resistant strains of Plasmodium falciparum parasite. In recent times, artemisinin (ART)-based drugs and combination therapies become the drugs of preference for the treatment and prophylaxis of resistant P. falciparum malaria. Endoperoxide compounds natural, semi-synthetic or synthetic signifying a massive number of antimalarial agents which possess a wide structural miscellany with needed antimalarial effectiveness against resistant P. falciparum malaria. The 1,2,4-trioxane ring system deficient the lactone ring which constitutes the most significant endoperoxide structural scaffold which is believed to be the key pharmacophoric moiety and is principally responsible for the pharmacodynamic potential of endoperoxide-based antimalarials. This becomes the main reason for the research related to endoperoxide particularly 1,2,4-trioxane-, 1,2,4-trioxolane- and 1,2,4,5-tetraoxane-based scaffolds gaining the noteworthy interest in recent years for developing antimalarial drugs against resistant malaria. In this paper, a comprehensive endeavour has been made to review the development of different endoperoxide antimalarial agents and structural diversity of endoperoxide molecules derived from 1,2,4-trioxane- based structural scaffolds.


Keywords: Endoperoxide; 1,2,4-trioxane; pharmacophores; artemisinin; antimalarial.               

Keywords: Endoperoxide, 1,2,4-trioxane., pharmacophores, artemisinin, antimalarial

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Author Biographies

Amit Choudhary, Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Manish Sinha, Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Arti Devi, Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Shammy Jindal, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Distt.- Kangra, H.P., India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Distt.- Kangra, H.P., India

Kamya Goyal, Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Distt-Kangra, H.P., India

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Choudhary A, Sinha M, Devi A, Jindal S, Goyal K. A Review on Antimalarial 1,2,4-Trioxane Derivatives. JDDT [Internet]. 15Aug.2020 [cited 23Apr.2021];10(4-s):240-53. Available from: http://jddtonline.info/index.php/jddt/article/view/4268