Comparative extraction, phytochemical screening and in vitro biological activities of Eclipta prostrata extract

  • Zafar Alam Khan TIT- Pharmacy Education and Research, Bhopal, India
  • Salaj Khare TIT- Pharmacy Education and Research, Bhopal, India
  • B.K. Dubey Pharmacology Departments, TIT-Pharmacy Education and Research, Bhopal, India

Abstract

Medicinal plants possess therapeutic potential and are used to treat various diseases around the world. Eclipta prostrate (L.) is a medicinal herb that has extensive application in the native medicinal system. In any therapeutic activity chemical constituents play an important role. Eclipta prostrata has been investigated in this study for its antioxidant, antimicrobial and antidiabetic activity in vitro. The well-known research protocol available in the literature established qualitative analysis of the different phytochemical constituents and quantitative analysis of total phenol and flavonoids. The hydroalcoholic extracts of the leaves and seeds of Eclipta prostrata exhibited significant and dose-dependent antioxidant activity including ability to donate electron. To analyze the antimicrobial activity, Leaves hydroalcoholic extracts and Eclipta prostrate seeds were tested against two selected strains using a well-diffusion method and showing significant inhibitory action against all the strain tested. In addition, the dose-dependent α-amylase inhibitory activity with an IC50 value of acarbose, leaves, and seed extract was found to be 364.89μg/ml and 438.43μg/ml, respectively, indicating that Eclipta prostrate is a promising source as an herbal medicine.


Keywords: Eclipta prostrate, Phytochemical Analysis, Antioxidant, Antimicrobial, Antidiabetic Activity.

Keywords: Eclipta prostrate, Phytochemical Analysis, Antioxidant, Antimicrobial, Antidiabetic Activity

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Author Biographies

Zafar Alam Khan, TIT- Pharmacy Education and Research, Bhopal, India

TIT- Pharmacy Education and Research, Bhopal, India

Salaj Khare, TIT- Pharmacy Education and Research, Bhopal, India

TIT- Pharmacy Education and Research, Bhopal, India

B.K. Dubey, Pharmacology Departments, TIT-Pharmacy Education and Research, Bhopal, India

Pharmacology Departments, TIT-Pharmacy Education and Research, Bhopal, India

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Khan ZA, Khare S, Dubey B. Comparative extraction, phytochemical screening and in vitro biological activities of Eclipta prostrata extract. JDDT [Internet]. 15Aug.2020 [cited 22Apr.2021];10(4-s):148-52. Available from: http://jddtonline.info/index.php/jddt/article/view/4263