Association of Gout with Rheumatoid Arthritis and Pulmonary Toxicity of Methotrexate: A Case Report about Algerian Women

  • Siheme Ouali Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Khalida ZEMRI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Khedoudja KANOUN Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Noria HARIR Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Zahira BENAISSA Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Feriel SELLAM National Research Center of Biotechnology. CRBT
  • Karima KAROUBI Department of internal medicine, EPH Benisaf- AinTemouchent, Algeria
  • Sid Tadj HEBRI Department of internal medicine, CHU Sidi BelAbbes,Algeria

Abstract

Coexistence of rheumatoid arthritis and gout is considered as rare  however some patients may gather both diseases. Long-term treatment with Methotrexate may cause pulmonary pathology. We report a case  of a 48-year-old Algerian  woman with medical history (swelling of knee  and  joint pain in the shoulders and hands)  diagnosed with  Rheumatoid  Arthritis  (RA), after  3 years of  self-medication with Methotrexate;  she returned with hyperurecimia that   confirmed the co-presence of the gout and RA as well as a pneumonia confirmed with clinical  sign and chest X-Ray. Methotrexate dose compliance can reduce adverse effects.


Keywords: Rheumatoid arthritis; Gout; Pneumonia; Methotrexate; Toxicity.

Keywords: Rheumatoid arthritis, Gout, Pneumonia, Methotrexate, Toxicity

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References

1. Andia A, Alassane S, Brah S, Daou M, Hamadou A , Adehossi E , Cheour E Rheumatoid Arthritis at The National Hospital of Niamey: A 42 cases report. Revue africaine de médecine interne (RAFMI), 2016; 3(2):29-32.
2. Shi Y, Mucsi AD, Ng G. Monosodium urate crystals in inflammation and immunity. Immunol Rev, 2010; 233:203-17.
3. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature, 2006; 440:237-41.
4. Kuo CF, Tsai WP, Liou LB. Rare copresent rheumatoid arthritis and gout: comparison with pure rheumatoid arthritis and a literature review. Clin Rheumatol, 2008; 27:231–5.
5. Jebakumar AJ, Udayakumar PD, Crowson CS, et al. Occurrenceof gout in rheumatoid arthritis: it does happen! A population-based study. Int J Clin Rheum, 2013; 8:433–7.
6. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum, 2011; 63(10):3136–3141.
7. Gubner R, August S, Ginsberg V. Therapeutic suppression of tissue reactivity. II. Effect of aminopterin in rheumatoid arthritis and psoriasis. Am J Med Sci, 1951; 221:176-182.
8. Clarysee AM, Cathey WJ, Cartwright GE, et al. Pulmonary disease complicating intermittent therapy with methotrexate. JAMA, 1969; 209:1861e1864.
9. SOSTMAN HD, MATTHAY RA, PUTMAN CE. Cytotoxic drug induced lung disease. Am. J. Med, 1977; 62:608-615.
10. DAY RO, QUINN DI, BROOKS PM, CONAGHAN PG. Hazards of low dose methotrexate. Aust. NZ. J. Med, 1995; 25:670-674.
11. KREMER JM, ALARCON GS, WEINBLATT ME et al. Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis. A multicenter study with literature review. Arthritis Rheum, 1997; 40:1829-1837.
12. Yunt, Z. X., & Solomon, J. J. Lung Disease in Rheumatoid Arthritis. Rheumatic Disease Clinics of North America, 2015; 41(2):225–236.
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Ouali S, ZEMRI K, KANOUN K, HARIR N, BENAISSA Z, SELLAM F, KAROUBI K, HEBRI ST. Association of Gout with Rheumatoid Arthritis and Pulmonary Toxicity of Methotrexate: A Case Report about Algerian Women. JDDT [Internet]. 15Jul.2020 [cited 4Aug.2020];10(4):216-8. Available from: http://jddtonline.info/index.php/jddt/article/view/4262

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