Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region

  • Zahira BENAISSA Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Khedoudja KANOUN Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Khalida ZEMRI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Noria HARIR Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • siheme OUALI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Feriel SELLAM National Research Center of Biotechnology. CRBT
  • Douniazad ELMEHADJI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Lahcen BELHANDOUZ Department of digestive and laparoscopic surgery, CHU SidiBel Abbes, Algeria
  • Mustapha ELAIB Department of digestive and laparoscopic surgery, EHU ORAN, Algeria

Abstract

Background: Crohn's disease is a chronic and recurrent inflammatory bowel disease that progresses slowly. Also CD patients have a large number of extra-intestinal manifestations.


Objective: we sought to define the possible associations between inflammatory pathology and localization and on the other hand, inflammatory pathologies and the disease behavior


Methods: A retrospective analytical study was carried out at the level of gastric and general surgery services of Western Algerian University Hospital of Sidi Bel Abbes region, during the period 2007-2019.


Results Our study was based on a total sample of 295 cases involving 114 females (38.6%) and 181 males (61.4%) with a sex ratio of (1.58). The location of the disease at the time of diagnosis was dominated by the ileo-caecal location (55.3%), of which 64.4% were associated with inflammatory pathology (IP). The majority of patients diagnosed with Crohn's disease had an inflammatory behavior and this for all age groups. The appendix, the ulcer and inflammatory anemia are most associated with Crohn’s disease. For inflammatory extra-intestinal manifestations, only group of patients with arthralgia had significantly higher rates in the 20-60 age groups. The mainly noted risk factors were appendectomy with (17.3%), smoking (22.4%) with a highly significant association, and alcoholism (6.1%).


Conclusion According to our results the association of inflammatory pathology and crohn disease is more frequent in male and dominated by arthralgia as extra-intestinal manifestations lesions.


Keywords: Crohn disease; Inflammatory pathology; disease behavior; inflammatory extra-intestinal manifestation.

Keywords: Crohn disease, Inflammatory pathology, disease behavior, inflammatory extra-intestinal manifestation

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BENAISSA Z, KANOUN K, ZEMRI K, HARIR N, OUALI siheme, SELLAM F, ELMEHADJI D, BELHANDOUZ L, ELAIB M. Association of Inflammatory Pathologies and Crohn’s Disease: A Retrospective Study in the West Algerian Region. JDDT [Internet]. 15Jul.2020 [cited 30Nov.2020];10(4):161-7. Available from: http://jddtonline.info/index.php/jddt/article/view/4244

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