Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region
Background: Crohn's disease is a chronic and recurrent inflammatory bowel disease that progresses slowly. Also CD patients have a large number of extra-intestinal manifestations.
Objective: we sought to define the possible associations between inflammatory pathology and localization and on the other hand, inflammatory pathologies and the disease behavior
Methods: A retrospective analytical study was carried out at the level of gastric and general surgery services of Western Algerian University Hospital of Sidi Bel Abbes region, during the period 2007-2019.
Results Our study was based on a total sample of 295 cases involving 114 females (38.6%) and 181 males (61.4%) with a sex ratio of (1.58). The location of the disease at the time of diagnosis was dominated by the ileo-caecal location (55.3%), of which 64.4% were associated with inflammatory pathology (IP). The majority of patients diagnosed with Crohn's disease had an inflammatory behavior and this for all age groups. The appendix, the ulcer and inflammatory anemia are most associated with Crohn’s disease. For inflammatory extra-intestinal manifestations, only group of patients with arthralgia had significantly higher rates in the 20-60 age groups. The mainly noted risk factors were appendectomy with (17.3%), smoking (22.4%) with a highly significant association, and alcoholism (6.1%).
Conclusion According to our results the association of inflammatory pathology and crohn disease is more frequent in male and dominated by arthralgia as extra-intestinal manifestations lesions.
Keywords: Crohn disease; Inflammatory pathology; disease behavior; inflammatory extra-intestinal manifestation.
2. Lo Re G, Cappello M, Tudisca C, Galia M, Randazzo C, Craxì A, et al. CT enterography as a powerful tool for the evaluation of inflammatory activity in Crohn’s disease: relationship of CT findings with CDAI and acute-phase reactants. Radiol med, 2014; 119(9):658‑66.
3. Cheifetz AS. Management of Active Crohn Disease. JAMA, 2013; 309(20):2150.
4. Wiens J, Rankin JA, Then KL. Arthropathies in Inflammatory Bowel Disease: A Review for Clinicians. Gastroenterology Nursing, 2017; 40(6):496‑503.
5. Abegunde AT, Muhammad BH, Bhatti O, Ali T. Environmental risk factors for inflammatory bowel diseases: Evidence based literature review. WJG, 2016; 22(27):6296.
6. Loureiro ACCF, Barbosa LER. Appendectomy and Crohn’s Disease. Journal of Coloproctology, 2019; 39(4):373‑80.
7. Herzog D, Fournier N, Buehr P, Rueger V, Koller R, Heyland K, et al. Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications: European Journal of Gastroenterology & Hepatology, 2018; 30(6):598‑607.
8. Al Fadda M, Peedikayil MC, Kagevi I, Al Kahtani K, Al Ben Mousa A, Al Ashgar HI, et al. Inflammatory bowel disease in Saudi Arabia: a hospital-based clinical study of 312 patients. Annals of Saudi medicine, 2012; 32(3):276–282.
9. Adler J, Dong S, Eder SJ, Dombkowski KJ. Perianal Crohn Disease in a Large Multicenter Pediatric Collaborative: Journal of Pediatric Gastroenterology and Nutrition, 2017; 64(5):e117‑24.
10. Aida I, Meddour Y, Kadiri H, Smara M, Bousseloub A, Kecili L, et al. T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients. Current Research in Translational Medicine, 2018; 66(1):9‑14.
11. Duarte-Silva M, Afonso PC, de Souza PR, Peghini BC, Rodrigues-Júnior V, de Barros Cardoso CR. Reappraisal of antibodies against Saccharomyces cerevisiae (ASCA) as persistent biomarkers in quiescent Crohn’s disease. Autoimmunity, 2019; 52(1):37‑47.
12. Caini S, Bagnoli S, Palli D, Saieva C, Ceroti M, Bendinelli B, et al. Total and cancer mortality in a cohort of ulcerative colitis and Crohn’s disease patients: The Florence inflammatory bowel disease study, 1978–2010. Digestive and Liver Disease, 2016; 48(10):1162‑7.
13. Medarhi J, Elounami M, Echarrab M, Amraoui M. Maladie de Crohn, place de la chirurgie en urgence à propos de 28 cas. Médecine du Maghreb, 2001; 90:52–8.
14. Cohen S, Padlipsky J, Yerushalmy-Feler A. Risk factors associated with extraintestinal manifestations in children with inflammatory bowel disease. Eur J Clin Nutr, 2020; 74(5):691‑7.
15. Liu S, Ding J, Wang M, Zhou W, Feng M, Guan W. Clinical features of Crohn disease concomitant with ankylosing spondylitis: A preliminary single-center study. Medicine, 2016; 95(28):e4267.
16. Bandyopadhyay D, Bandyopadhyay S, Ghosh P, De A, Bhattacharya A, Dhali GK, et al. Extraintestinal manifestations in inflammatory bowel disease: Prevalence and predictors in Indian patients. Indian J Gastroenterol, 2015; 34(5):387‑94.
17. Mücke V. Diagnosis and treatment of anemia in patients with inflammatory bowel disease. aog [Internet]. 2016 [cité 28 juin 2020]; Disponible sur: http://www.annalsgastro.gr/files/journals/1/earlyview/2016/ev-09-2016-07-AG2764-0083.pdf
18. Saade C, Nasr L, Sharara A, Barada K, Soweid A, Murad F, et al. Crohn’s disease: A retrospective analysis between computed tomography enterography, colonoscopy, and histopathology. Radiography, 2019; 25(4):349‑58.
19. Basturk A, Artan R, Yılmaz A, Gelen MT. Gastritis Associated with Initially Pediatric Crohn’s Disease and Ulcerative Colitis. Pediatr Gastroenterol Hepatol Nutr, 2018; 21(3):163.
20. Hsu Y-C, Wu T-C, Lo Y-C, Wang L-S. Gastrointestinal complications and extraintestinal manifestations of inflammatory bowel disease in Taiwan: A population-based study. Journal of the Chinese Medical Association, 2017; 80(2):56‑62.
21. Bronner MP. Granulomatous appendicitis and the appendix in idiopathic inflammatory bowel disease. Seminars in Diagnostic Pathology, 2004; 21(2):98‑107.
22. Burr NE, Lord R, Hull MA, Subramanian V. Decreasing Risk of First and Subsequent Surgeries in Patients With Crohn’s Disease in England From 1994 through 2013. Clinical Gastroenterology and Hepatology, 2019; 17(10):2042-2049.e4.
23. Kaplan GG, Jackson T, Sands BE, Frisch M, Andersson RE, Korzenik J. The Risk of Developing Crohn’s Disease After an Appendectomy: A Meta-Analysis. The American Journal of Gastroenterology, 2008; 103(11):2925‑31.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).