Is there an association between Anti-Citrullinated Peptide Antibodies and the Severity of Rheumatoid Arthritis Parameters in Algerian Patients?

  • siheme OUALI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Khalida ZEMRI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria
  • Ferial SELLAM National Research Center of Biotechnology. CRBT
  • Noria HARIR Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Zahira BENIASSA Department of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria
  • Sid Tadj HEBRI Department of internal medicine, CHU Sidi BelAbbes,Algeria
  • Ouassini BENSABER Department of functional rehabilitation, CHU Sidi Bel Abbes, Algeria
  • Douniazad ELMEHADJI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria
  • Zouaoui NADJI Department of internal medicine, CHU Sidi BelAbbes,Algeria
  • Karima KAROUBI Department of internal medicine, EPH Benisaf- AinTemouchent, Algeria


Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages and laboratory assessment in Algerian patients with Rheumatoid arthritis, as well as their importance like a predictive factor for the diagnosis of Rheumatoid arthritis (RA).

Methods: 281 patients diagnosed with RA according to ACR 1987 criteria in the  internal medicine and Functional Rehabilitation departments (the University Hospital of Sidi Bel Abbes) were enrolled in the study based on medical records including age, gender, disease duration, disease activity score (DAS28), joint damages, laboratory tests and treatment. All data were processed and analyzed via SPSS 22.0.

Results: 86.5% of patients were females with a mean age and disease duration of respectively 52.665±12.3477, 4.19±4.050.  Patients with Anti-CCP positive (79.7%) presented a high disease activity (p<0.0001), a long disease duration (p=0.016) and a erosion damages (p<0.0001). we did not found any significant relation between gender, hands damages and CRP..A logistic regression showed that the presence of Anti-CCP was associated with Erosion, disease activity, age and RF presence.

Conclusion: There was a strong relation between Anti-CCP antibodies status and the development of RA in Algerian patients. It could be considered as a useful predictor of disease severity.


Keywords: Rheumatoid Arthritis, Algerian Patients, Anti-Citrullinated Peptide/Protein Antibodies, Disease activity, Erosion, Severity


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OUALI siheme, ZEMRI K, SELLAM F, HARIR N, BENIASSA Z, HEBRI ST, BENSABER O, ELMEHADJI D, NADJI Z, KAROUBI K. Is there an association between Anti-Citrullinated Peptide Antibodies and the Severity of Rheumatoid Arthritis Parameters in Algerian Patients?. JDDT [Internet]. 15Jul.2020 [cited 30Nov.2020];10(4):17-4. Available from:

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