Antioxidant and hepatoprotective Potential of Coriandrum sativum L. against hepatic injury by Lambda-cyhalothrin insecticide
Abstract
The objective of this study is to evaluate the antioxidant and hepatoprotective activity of aerial part and seeds of Coriandrum sativum plant against Lambda cyhalothrin insecticide. Male Wistar Albinos rats were randomly divided into control, LCT, CsA, CsS, CsS+LCT, CsA+LCT groups, after 90 days of treatments Biochemical, some oxidative stress parameters, and histopathology of liver tissue were evaluated. Total polyphenol content in aerial part and the seed extract estimated at 9.29 and 14.64 mg EAG / mg of extract and IC50 for an antioxidant activity equal to 19.38 and 22.62 mg/ml respectively. The obtained results revealed that rats received Lambda cyhalothrin insecticide showed a significant change in enzymes activity (AST, ALT, ALP and c-GT) and Glutathione (GSH) in liver. Meanwhile content of hepatic Malondialdehyde (MDA). Histopathology examination of liver revealed that Coriandrum sativum attenuate the incidence of liver lesions triggered by Lambda cyhalothrin intoxication. Therefore, the results of this study show that Coriandrum sativum can be proposed to protect the liver against Lambda cyhalothrin induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect.
Keywords: hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress.
Keywords:
hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress
Downloads
Download data is not yet available.
References
[1] Gurpreet K, Sarwar Alam M, Zoobi J, Kaleem J, Mohammad A. Evaluation of antioxidant activity of Cassia siamea flowers. J.Ethnopharmacol 2006; 108:340-348.
[2] Shaker ME, Zalata KR, Mehal WZ, Shiha GE, Ibrahim TM. Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis. Toxicol. Appl. Pharmacol 2011; 252:165-175.
[3] Gachkar L, Yadegari D, Rezaei MB, Taghizadeh M, Astaneh SA, Rasooli I. Chemical and biological characteristics of Cuminum cyminum and Rosmarinus officinalis essential oils. Food Chem 2007; 02:898-904.
[4] Muthamma Milan KS, Dholakia H, Kaultiku P, Vishveshwaraiah P. Enhancement of digestive enzymatic activity by cumin (Cuminum cyminum L.) and role of spent cumin as a bionutrient. Food Chem 2008; 110(3):678-683.
[5] Cazzi R, Ricardy R, Aglitti T, Gatta V, Petricone P, De Salvia R. Ascorbic acid and b-carotene as modulators of oxidative damage; Carcinog 1997; 18:223–228.
[6] Vitaglione P, Morisco F, Caporaso N, Fogliano V. Dietary Antioxidant compounds and liver health. Crit Rev Food Sci Nutr 2004; 44(78):575-86.
[7] Bouquet A. Plantes médicinales du Congo-Brazzaville; Uvariopsis, Pauridiantha, Diospyros ... Paris, Ed: O.R.S.T.O.M. 1972: No. 13.
[8] Li HB, Cheng KW, Wong CC, Fan KW, Chen F, Jiang Y. Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae. Food Chem 2007; 102:771-776.
[9] Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am J Enol Viticult 1965; 16:144-158.
[10] Mansouri A, EmbarekG, Kokkalou E, kefalas P. Phenolic profile and antioxidant activity of the Algerian ripe date fruit (phonix dactylifera). Food Chem 2005; 89:411-420.
[11] Torres R, Faini F, Modak B, Urbina F, Labbe´ C, Guerrero J. Antioxidant activity of coumarins and flavonols from the resinous exudate of Haplopappus multifolius. Phytochemistry 2006; 67:984-987.
[12] Bradford MM. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 1976; 72:248-254.
[13] Weckbercker G, Cory JG. Ribonucleotide reductase activity and growth of glutathione-depleted mouse leukemia L1210 cells in vitro. Cancer Letters 1988; 40(3):257-264.
[14] Quintanilha AT, Packer L, Davies J MS, Racanelli TL, Davies KJA. Membrane effects of vitamin E deficiency: bioenergetic and surface charge density studies of skeletal muscle and liver mitochondria. Ann. N. Y. Acad. Sci. 1982; 393:32-47.
[15] Wei TY, Hsueh PH, Wen SH, Chen CL, Wang CC. The Role of Tea and Coffee in the development of gastroesophageal reflux disease, Tzu Chi Medical Journal 2019; 31(3):169-176.
[16] Marangoni C, Moura, NF. Antioxidant activity of essential oil from Coriandrum Sativum L. in Italian salami. Ciencia Tecnol Alime 2011; 31(1):124-128.
[17] Sultana S, Ripa FA, Hamid K. Comparative antioxidant activity study of some commonly used spices in Bangladesh. Pakistan J Biol Sci 2010; 13(7):340-343.
[18] Mageed MAAE, Mansour AF, El Massry K.F, Ramadan M.M, Shaheen M.S, Shaaban H., Effect of microwaves on essential oils of coriander and cumin seeds and on their antioxidant and antimicrobial activities. J Essent Oil Bear Pl 2012; 15(4):614-627.
[19] Huang QF, Zhang SJ, Zheng L, Huang RB, Lin X. Hepatoprotective effects of total saponis isolated from Tarathochlamys affinis against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol 2012; 50:713-718.
[20] Singh B, Saxena AK, Chandan BK, Anand KK, Suri OP, Surisatti KA, Surisatti NK. Hepatoprotective activity of verbenalin on experimental liver damage in rodents. Fit 1998; 69:134-140.
[21] Ozturk IC, Ozturk F, Gul M, Ates B, Cetin A. Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats. Cell Biochem Funct 2009; 27:309-315.
[22] Himmerich H, Kaufmann C, Schuld A, Pollmacher T. Elevation of liver enzyme levels during psychopharmacological treatment is associated with weight gain. J Psychiatr Res 2005; 39: 35-42.
[23] Liappas I, Piperi C, Malitas PN, Tzavellas EO, Zisaki A, Liappas AI, Kalofoutis CA, Boufidou F, Bagos P, Rabavilas A. Interrelationship of hepatic function, thyroid activity and mood status in alcohol-dependent individuals. Toxicology 2006; 20: 293-300.
[24] Michailova A, Kuneva T, Popov TA. Comparative assessment of liver function in workers in the petroleum industry. Int. Arch. Occup. Environ. Health 1998; 71:46-49.
[25] Fang J, Sawa T, Maeda H. Factors and mechanism of EPR effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. Adv Exp Med Biol 2003; 519:29-49.
[26] Ogeturka M, Kusa I, Colakoglub N, Zararsiza I, Ilhanc N, Sarsilmaz M, Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J. Ethnopharmacol 2005; 97:273-280.
[27] Franco R, Panayiotidis MI, Cidlowski JA. Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. Journal of biological chemistry 2007; 282(42):30452-30465.
[28] Venukumar MR, Latha MS. Antioxidant activity of Curculigo orchioides in carbon tetrachloride-induced hepatopathy in rats. J Clin Biochem 2002; 17:80-87.
[29] Weber LWD, Bool M, Stampfl A, Hepatototoxicity and machenism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33:105-136.
[30] Kyle ME, Miccadei S, Nakae D, Farber JL. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem. Biophys. Res. Commun 1987; 149:889-896.
[31] Zeghib K, Djahra AB. Protective role of aqueous extract of Atriplex halimus L. Against benzene-induced damage on renal function and glomerular cells in rats. Asian J Pharm Clin Res 2019; 12(3):387-392.
[2] Shaker ME, Zalata KR, Mehal WZ, Shiha GE, Ibrahim TM. Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis. Toxicol. Appl. Pharmacol 2011; 252:165-175.
[3] Gachkar L, Yadegari D, Rezaei MB, Taghizadeh M, Astaneh SA, Rasooli I. Chemical and biological characteristics of Cuminum cyminum and Rosmarinus officinalis essential oils. Food Chem 2007; 02:898-904.
[4] Muthamma Milan KS, Dholakia H, Kaultiku P, Vishveshwaraiah P. Enhancement of digestive enzymatic activity by cumin (Cuminum cyminum L.) and role of spent cumin as a bionutrient. Food Chem 2008; 110(3):678-683.
[5] Cazzi R, Ricardy R, Aglitti T, Gatta V, Petricone P, De Salvia R. Ascorbic acid and b-carotene as modulators of oxidative damage; Carcinog 1997; 18:223–228.
[6] Vitaglione P, Morisco F, Caporaso N, Fogliano V. Dietary Antioxidant compounds and liver health. Crit Rev Food Sci Nutr 2004; 44(78):575-86.
[7] Bouquet A. Plantes médicinales du Congo-Brazzaville; Uvariopsis, Pauridiantha, Diospyros ... Paris, Ed: O.R.S.T.O.M. 1972: No. 13.
[8] Li HB, Cheng KW, Wong CC, Fan KW, Chen F, Jiang Y. Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae. Food Chem 2007; 102:771-776.
[9] Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am J Enol Viticult 1965; 16:144-158.
[10] Mansouri A, EmbarekG, Kokkalou E, kefalas P. Phenolic profile and antioxidant activity of the Algerian ripe date fruit (phonix dactylifera). Food Chem 2005; 89:411-420.
[11] Torres R, Faini F, Modak B, Urbina F, Labbe´ C, Guerrero J. Antioxidant activity of coumarins and flavonols from the resinous exudate of Haplopappus multifolius. Phytochemistry 2006; 67:984-987.
[12] Bradford MM. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 1976; 72:248-254.
[13] Weckbercker G, Cory JG. Ribonucleotide reductase activity and growth of glutathione-depleted mouse leukemia L1210 cells in vitro. Cancer Letters 1988; 40(3):257-264.
[14] Quintanilha AT, Packer L, Davies J MS, Racanelli TL, Davies KJA. Membrane effects of vitamin E deficiency: bioenergetic and surface charge density studies of skeletal muscle and liver mitochondria. Ann. N. Y. Acad. Sci. 1982; 393:32-47.
[15] Wei TY, Hsueh PH, Wen SH, Chen CL, Wang CC. The Role of Tea and Coffee in the development of gastroesophageal reflux disease, Tzu Chi Medical Journal 2019; 31(3):169-176.
[16] Marangoni C, Moura, NF. Antioxidant activity of essential oil from Coriandrum Sativum L. in Italian salami. Ciencia Tecnol Alime 2011; 31(1):124-128.
[17] Sultana S, Ripa FA, Hamid K. Comparative antioxidant activity study of some commonly used spices in Bangladesh. Pakistan J Biol Sci 2010; 13(7):340-343.
[18] Mageed MAAE, Mansour AF, El Massry K.F, Ramadan M.M, Shaheen M.S, Shaaban H., Effect of microwaves on essential oils of coriander and cumin seeds and on their antioxidant and antimicrobial activities. J Essent Oil Bear Pl 2012; 15(4):614-627.
[19] Huang QF, Zhang SJ, Zheng L, Huang RB, Lin X. Hepatoprotective effects of total saponis isolated from Tarathochlamys affinis against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol 2012; 50:713-718.
[20] Singh B, Saxena AK, Chandan BK, Anand KK, Suri OP, Surisatti KA, Surisatti NK. Hepatoprotective activity of verbenalin on experimental liver damage in rodents. Fit 1998; 69:134-140.
[21] Ozturk IC, Ozturk F, Gul M, Ates B, Cetin A. Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats. Cell Biochem Funct 2009; 27:309-315.
[22] Himmerich H, Kaufmann C, Schuld A, Pollmacher T. Elevation of liver enzyme levels during psychopharmacological treatment is associated with weight gain. J Psychiatr Res 2005; 39: 35-42.
[23] Liappas I, Piperi C, Malitas PN, Tzavellas EO, Zisaki A, Liappas AI, Kalofoutis CA, Boufidou F, Bagos P, Rabavilas A. Interrelationship of hepatic function, thyroid activity and mood status in alcohol-dependent individuals. Toxicology 2006; 20: 293-300.
[24] Michailova A, Kuneva T, Popov TA. Comparative assessment of liver function in workers in the petroleum industry. Int. Arch. Occup. Environ. Health 1998; 71:46-49.
[25] Fang J, Sawa T, Maeda H. Factors and mechanism of EPR effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. Adv Exp Med Biol 2003; 519:29-49.
[26] Ogeturka M, Kusa I, Colakoglub N, Zararsiza I, Ilhanc N, Sarsilmaz M, Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J. Ethnopharmacol 2005; 97:273-280.
[27] Franco R, Panayiotidis MI, Cidlowski JA. Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. Journal of biological chemistry 2007; 282(42):30452-30465.
[28] Venukumar MR, Latha MS. Antioxidant activity of Curculigo orchioides in carbon tetrachloride-induced hepatopathy in rats. J Clin Biochem 2002; 17:80-87.
[29] Weber LWD, Bool M, Stampfl A, Hepatototoxicity and machenism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33:105-136.
[30] Kyle ME, Miccadei S, Nakae D, Farber JL. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem. Biophys. Res. Commun 1987; 149:889-896.
[31] Zeghib K, Djahra AB. Protective role of aqueous extract of Atriplex halimus L. Against benzene-induced damage on renal function and glomerular cells in rats. Asian J Pharm Clin Res 2019; 12(3):387-392.
Crossmark
Statistics
473 Views | 365 Downloads
How to Cite
1.
DJAHRA AB, BENKADDOUR M, BENKHERARA S, OUAHIBA B. Antioxidant and hepatoprotective Potential of Coriandrum sativum L. against hepatic injury by Lambda-cyhalothrin insecticide. JDDT [Internet]. 22Jun.2020 [cited 20May2024];10(3-s):182-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4186
Section
Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.