Antioxidant and hepatoprotective Potential of Coriandrum sativum L. against hepatic injury by Lambda-cyhalothrin insecticide

  • Ali Boutlelis DJAHRA El-Oued University, BES Laboratory, Fac. Natural Science and Life, 39000 El-Oued, Algeria
  • Mounia BENKADDOUR El-Oued University, BES Laboratory, Fac. Natural Science and Life, 39000 El-Oued, Algeria
  • Salah BENKHERARA Ghardaia University, Fac of Natural Science and Life, 47000 Ghardaia, Algeria
  • Bordjiba OUAHIBA University of Annaba, PBE Laboratory, Fac. Sciences / 23000Annaba, Algeria

Abstract

The objective of this study is to evaluate the antioxidant and hepatoprotective activity of aerial part and seeds of Coriandrum sativum plant against Lambda cyhalothrin insecticide.  Male Wistar Albinos rats were randomly divided into control, LCT, CsA, CsS, CsS+LCT, CsA+LCT groups, after 90 days of treatments Biochemical, some oxidative stress parameters, and histopathology of liver tissue were evaluated. Total polyphenol content in aerial part and the seed extract estimated at 9.29 and 14.64 mg EAG / mg of extract and IC50 for an antioxidant activity equal to 19.38 and 22.62 mg/ml respectively. The obtained results revealed that rats received Lambda cyhalothrin insecticide showed a significant change in enzymes activity (AST, ALT, ALP and c-GT) and Glutathione (GSH) in liver. Meanwhile content of hepatic Malondialdehyde (MDA). Histopathology examination of liver revealed that Coriandrum sativum attenuate the incidence of liver lesions triggered by Lambda cyhalothrin intoxication. Therefore, the results of this study show that Coriandrum sativum can be proposed to protect the liver against Lambda cyhalothrin induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect.


Keywords: hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress.

Keywords: hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress

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Author Biographies

Ali Boutlelis DJAHRA, El-Oued University, BES Laboratory, Fac. Natural Science and Life, 39000 El-Oued, Algeria

El-Oued University, BES Laboratory, Fac. Natural Science and Life, 39000 El-Oued, Algeria

Mounia BENKADDOUR, El-Oued University, BES Laboratory, Fac. Natural Science and Life, 39000 El-Oued, Algeria

El-Oued University, BES Laboratory, Fac. Natural Science and Life, 39000 El-Oued, Algeria

Salah BENKHERARA, Ghardaia University, Fac of Natural Science and Life, 47000 Ghardaia, Algeria

Ghardaia University, Fac of Natural Science and Life, 47000 Ghardaia, Algeria

Bordjiba OUAHIBA, University of Annaba, PBE Laboratory, Fac. Sciences / 23000Annaba, Algeria

University of Annaba, PBE Laboratory, Fac. Sciences / 23000Annaba, Algeria

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DJAHRA AB, BENKADDOUR M, BENKHERARA S, OUAHIBA B. Antioxidant and hepatoprotective Potential of Coriandrum sativum L. against hepatic injury by Lambda-cyhalothrin insecticide. JDDT [Internet]. 22Jun.2020 [cited 2Jul.2020];10(3-s):182-8. Available from: http://jddtonline.info/index.php/jddt/article/view/4186