Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts
Abstract
Obesity is a condition in which large amount of fat is stored in adipose tissue. Obesity is the greatest risk for many diseases like coronary heart disease, type 2 diabetes millions associated with insulin resistance, arthritis disorder, hypertension and cancers. Currently, the available drugs for obesity have been associated with number of side effects when compared with allopathic drugs. Salvia hispanica was one of the member of Lamiaceae family, collected to study the antiobesity activity. Extraction of Salvia hispanica using different solvents was done and tested for the presence of phytochemical constituents and the antimicrobial activity was monitored to evaluate the zone of inhibition. Further, antioxidant potential activity such as DPPH, FRAP and H2O2 assay was studied. Percentage of inhibition of Salvia hispanica was calculated and was observed as in capturing the free radicals present in the body. The surface and cross-sectional morphology Salvia hispanica extract nanoparticles was examined by using SEM. High ALA content make chia a perfect as it is associated with lower incidence of Cardiovascular diseases. This metabolic syndrome is mediated by inflammatory pathways. Hence, the in vitro activity of anti-inflammatory assay was performed by inhibition of albumin denaturation and anti-obesity activity was performed by lipase inhibition assay. Thus the result indicates that the seed extracts of Salvia hispanica possess antiobesity activity.
Keywords: Salvia hispanica, anti-obesity, cholesterol, Antioxidant, lipase inhibition
Downloads
References
2. Pagotto U, D. Vanuzzo, V. Vicennati, and R. Pasquali, “Pharmacological therapy of obesity,” Giornale Italiano di Cardiologia, 2008; 9(4); 83–93.
3. Sukhneet S, Santosh JP and Goyat. J, “Chia seed: Salvia hispanica- A new age functional food”, International Journal of Advanced Technology in Engineering and science, 2016; 4(3):978-86.
4. Sehrawat A, and Singh S, “Pharmacognostical standardization and preliminary phytochemical explorations on Salvia hispanica L. seeds”, 2019; 9(1):139-143.
5. Bhutani JE, Potter JD, Jacobs DR, Kopher RA and Rourke MJ, “Maternal waist-to-hip ratio as a predictor of newborn size: results of the diana project”, Epidemiology, 2007; 7:62–66.
6. Silva CSD, Monteiro CRDA, Silva GHF., Sarni, ROS, Souza, FIS, Feder D and Eberlin, M. N. “Assessing the Metabolic Impact of Ground Chia Seed in Overweight and Obese Prepubescent Children: Results of a Double-Blind Randomized Clinical Trial”. Journal of Medicinal Food. 2020; 23:224-232.
7. Souza T, Silva, SV, Faria, T, Silva, V, Fidalgo, C, & Citelli M “Chia oil induces browning of white adipose tissue in high-fat diet-induced obese mice”. Molecular and Cellular Endocrinology, 2020; 48:538-545.
8. Ayyappadasan G, Deepak kumar P, Rubavathi S and Uthira M, “ Metabolite profiling and an invitro assessment of antimicrobial and antioxidant activities of lichen Ramalina inflata”, International Research Journal of Pharmacy, 2017; 7(12):132-138.
9. Gazem RA, Puneeth HR, Chakere SC and Chandrashekaraih S, “Physiochemical properties and invitro Anti-inflammatory effects of Indian chia (Salvia hispanica) seed oil”, 2016; 11:01-08.
10. Rubavathi S and Ramya M Invitro Assessment of Antimicrobial and Antioxidant Activity of Bioactive Compounds from Marine Algae. International Journal of Current Microbiology and Applied Sciences, 2016; 5 (7):253-266.
11. Patil MM, Anand T, Ilaiyaraja and Farhath K. “Invitro Antioxidant and Antiobesity properties of Bauhinia variegate”, 2017;2:128-132.
12. Premkumar S, Rubavathi S, and Robinson JP, Green Synthesis of Silver Nanoparticles using Barringtonia Acutangula (l.) Gaertn. and its Invitro Anticancer Property, International Journal of Advance Research, Ideas and Innovations in Technology, 2018; 3 (6):322-331.
13. Changhyun R and Uhee J “Screening of crude plant extracts with Anti-obesity activity”, Int J Mol Sci. 2012; 13:1710-1719.
14. Das B, Choudhury MD, Dey A, Talukdar AD, Nongalleima KH and Deb L “Antioxidant and Anti-Inflammatory Activity of Aqueous and Methanolic Extracts of Rhizome Part of Drynaria Quercifolia (L.)” Internatonal journal of pharmacy and pharmaceutical sciences, 2014; 6:43-49.
15. Divyapriya GK, Veeresh DJ and Puja CY “Evaluation of Antibacterial efficacy of Chia seed extract against Porphyromonas Gingivalis, Fusobacterium. Nucleatum and Aggretibacter Actinomycetemcomitans- An in-vitro study”, International journal of Ayurvedha, 2016; 4:2322- 2355.
16. Jyoti S, Vetriselvan S, Gayathiri S, Ishwin S, Shereenjeet G, Devi CH, and Yaashini A. “Comparitive evaluation of anti-inflammatory activity of extract of Curcuma longa and standard drug in carrageenan induced paw edema model using albino wistar rats” International journal of biological and pharmaceutical research, 2012; 3:538-544.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).