Design and Synthesis of Novel Anticancer Peptide Nanoparticles

  • Zhi-Gang Sun Linyi Central Hospital, Linyi 276400, Shandong, China
  • Zhi-Na Li Linyi Central Hospital, Linyi 276400, Shandong, China
  • Bao-Chan Yang College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, Shandong, China
  • Liang-Hui Zhao School of Clinical Medicine, Weifang Medical University, Weifang 261000, Shandong, China

Abstract

Cancer has now become a common disease affecting human health. Existing cancer treatment drugs can no longer meet the growing needs of cancer patients, and the emergence of anticancer drug resistance has exacerbated this phenomenon. By designing and synthesizing new anticancer peptide nanoparticles and studying their anticancer effects, new strategies for cancer treatment may be obtained. Novel anticancer peptides are synthesized by adding basic amino acids and solid-phase synthesis technology, and their structural information is determined by mass spectrometry. Nanoparticles of anticancer peptide were synthesized by nano-self-assembly technology. Two novel anticancer peptides exhibited anticancer activity, one of which was assembled into nanoparticles. The theoretical isoelectric points of the modified SZG3 and SZG5 are all greater than physiological pH, and will be positively charged under physiological conditions. The estimated half-life of SZG3 and SZG5 is significantly extended (30h), which is beneficial to increase the efficacy and reduce toxic and side effects. SZG3 and SZG5 have a good inhibitory effect on tumor cells and have low toxicity to normal cells.


Keywords: anticancer peptide, study, design, cancer, nanoparticles 

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Author Biographies

Zhi-Gang Sun, Linyi Central Hospital, Linyi 276400, Shandong, China

Linyi Central Hospital, Linyi 276400, Shandong, China

Zhi-Na Li, Linyi Central Hospital, Linyi 276400, Shandong, China

Linyi Central Hospital, Linyi 276400, Shandong, China

Bao-Chan Yang, College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, Shandong, China

College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, Shandong, China

Liang-Hui Zhao, School of Clinical Medicine, Weifang Medical University, Weifang 261000, Shandong, China

School of Clinical Medicine, Weifang Medical University, Weifang 261000, Shandong, China

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Sun Z-G, Li Z-N, Yang B-C, Zhao L-H. Design and Synthesis of Novel Anticancer Peptide Nanoparticles. JDDT [Internet]. 15Jul.2020 [cited 4Aug.2020];10(4):102-7. Available from: http://jddtonline.info/index.php/jddt/article/view/4156