Histological study of the effects of aluminum chloride exposure on the brain of wistar rats female
the effects of aluminum chloride exposure on the brain of wistar rats female.
Introduction: Aluminum (Al) has the potential to be neurotoxic in human and animals, is present everywhere in the environment, many manufactured foods and medicines and is also added to drinking water for purification purposes and tooth paste cosmetic products They accumulate in living organisms and disrupt balances, and accumulate in the body biological systems, causing toxic effects (They may affect the nervous system, kidney, liver, respiratory or other functions). Nervous system is a vulnerable target for toxicants due to critical voltages which must be maintained in the cells and the all responses when voltages reach threshold levels.
Objective This study aimed to expose the impact of aluminum chloride (AlCl3) on brain architecture.
Methods: In our study, twenty healthy female rats were intraperitoneal administered of aluminum chloride (ALCL3) at 10 mg / kg body weight with consecutively for 15 day
Result. The results showed a highly significant reduction in body weight (p<0.0001). This is because aluminum has an anorectic effect contrariwise, there is no significant impact of aluminium exposure has been observed with respect to brain weight and relative brain weight respectively (p<0.912), (p<0.45).
The histological study describes the alterations in the brain marked tissue necrosis and cytoplasmic vacuolations and karyopyknosis of neuronal cells of the brain.
Conclusion; Aluminum is a toxic heavy metal and a ubiquitous environmental pollutant. It can alter the permeability of the blood-brain barrier and enter the brain, severely affecting the functioning of the nervous system.
Keywords: Toxicity, brain, Aluminium chloride, Rats female, necrosis.
2. Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metalassociated neurotoxicities. Hum Exp Toxicol 2007; 26: 221 – 9.
3. Buraimoh AA and Ojo SA. Effects of Aluminium Chloride Exposure on the Histology of the Stomach of Wistar Rats. Int J Pharm. Bio Sci.; Oct-Dec.2012b; vol2, Issue4, 266-276.
4. Buraimoh. A.A, S.A. Ojo, J.O. Hambolu and S.S. Adebisi, Asian J. Biol. Sci, 2012c, 3 (2): 435-438.
5. Buraimoh A.A. S.A. Ojo, J.O. Hambolu and S.S. Adebisi, American Medical Journal, 2012d, 3(2): 210-219.
6. M. Kawahara .Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases J. Alzheimers Dis., 8 (2005), pp. 171-182.
7. A.C. Miu, C.E. Andreescu, R. Vasiu, A.I. OlteanuA behavioral and histological study of the effects of long-term exposure of adult rats to aluminumInt. J. Neurosci., 113 (2003), pp. 1197-1211.
8. Walton, J.R.; Brain lesions comprised of aluminum-rich cells that lack microtubules may be associated with the cognitive deficit of Alzheimer’s disease Neurotoxicology, 30 (2009), pp. 1059-1069.
9. Graczyk A., Radomska K., Długaszek M. Synergizm i antagonizm między biopierwiastkami i metalami toksycznymi. Ochrona Środowiska i Zasobów Naturalych nr 18. Instytut Ochrony Środowiska. Warszawa, pp39-45, 1999
10. Plieth C., Sattelmacher B., Hansen U.P., Knight M.R. Low-pH-mediated in cytosolic calcium are inhibited by aluminium: a potential mechansm for aluminium toxicity. Plant.J.18 (6), 643, 1999.
11. Afifi A. Renal osteodystrophy in developing countries. Artif.Organs. 26 (9), 767, 2002.
12. Chen J., Wang M., Run D., She J. Early chronic aluminium exposure impairs long-term potentaion and depression to the rat dentate gyrus in vivo. Neuroscience,112 (4), 879, 2002.
13. Campbell A. The potential role of aluminium in Alzheimers disease. Nephrol.Dial. Transplant. 17,supl 2,17, 2002.
14. Y.L. Chan, A.C. Alfrey, S. Posen, D. Lissner, E. Hills, C.R. Dunstan and R.A. Evans, Calcif Tissue Int., 1983; 35: 344-351.
15. Bräunlich H. C. Fleck, L. Kersten, G. Stein, V. Laske, A. Müller and E. Keil, J Appl Toxicol, 1986; 6: 55-59.
16. Terry R. D. and Pena C. Experimental production of neurofibrillary degeneration..Neuropath. Exp. Neurol. 24: (1965) 200–21
17. A. Christine, the American Heritage Dictionary of Idioms. Published by Houghton Mifflin. 1997.
18. Hava M. AND Hurwtiz A. (lW3). The relaxing effect of aluminum and lanthanum on rat and human gastric smooth muscle in vitro. Eur. J. Plnrmncol. 22 : I 56- I 6 I ; 1973.
19. Hurwitz A. Robinson R. G,Vats T-S., Whittier F. C. AND Herin W.F. (1976). Effects of antacids on gristric emptying. Gastroenterolog7yI : 268-273.
20. Duterte-Boucher D, Leclère J-F, Panissaud C, Costentin J. Acute effects of direct dopamine agonists in the mouse behavioral despair test. European Journal of Pharmacology. September 1988. Volume 154, Issue 2, 13, Pages 185-190.
21. Brodal, S., 1992. The Central Nervous System: Structure and Function. Oxford University Press, Oxford. Cowling, S.J., A.M. Gunn and D.A. Winnard, 1991. Aluminium Speciation in drinking water. Report no. FRO192.
22. Cauller, L. (1995). Layer I of primary sensory neocortex: where top-down converges upon bottom-up. Behav Brain Res., 71(1-2):163-70. PMID 874718.
23. Crapper, D.R., S.S. Quittkat, Krishman, A.J. Dalton and U. De Boni, 1980. Intranuclear aluminum content in Alzheimer’s disease, dialysis encephalopathy and experimental aluminum encephalopathy acta Neuropathology, 50: 19-24.
24. Linton RW, Bryan SR, Grif fis DP, Shelburne JD, Fiori CE, Gar ruto RM. Digital imaging studies of aluminum and calcium in neurofibrillarytangle-bearing neurons using secondary ion mass spect romet ry. Trace Elem. Med., 1987: 4: 99-104 .
25. Muller,G., V. Bernuzzi, D. Desor, M.F. Hutin, D. Burnel and P.R. Lher, 1990. Developmental alteration in offspringoffemalerats orally intoxicated by aluminum lactate at different gestation periods. Teratol., 42: 253-261.
26. N. VanDuyn, R. Settivari, J. LeVora, S. Zhou, J. Unrine, R. Nass, The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration, J. Neurochem. 124 (2013) 147–157
27. Shukla, A., Shukla, G.S., Srimal, R.C., 1996. Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat. Hum. Exp. Toxicol. 15, 400–405
28. Wang, B., Du, Y., 2013. Cadmium and its neurotoxic effects. Oxid. Med. Cell. Longev. 2013 898034.
29. M. Nampoothiri, J. John, N. Kumar, J. Mudgal, G.K. Nampurath, M.R. Chamallamudi, Modulatory role of simvastatin against aluminium chloride-induced behavioural and biochemical changes in rats, Behav. Neurol. 2015 (2015) 1–9.
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