A Study on Prescribing Pattern of Antihypertensive in Chronic Kidney Disease Patients
Abstract
Background: Chronic kidney disease causes progressive loss of function which gradually occur overtime leading to decrease in GFR levels leading to dysfunction of renal system. Hypertension is found to be intermingled cause and overlapping complication in CKD. It is important to intervene the progression by controlling the blood pressure to prevent kidney failure by administration of anti-hypertensive. Objectives: To study current trends in anti-hypertensive prescription pattern in CKD patient and to evaluate the concurrent patterns are in adherence according to the guidelines mentioned. Methods: Prospective observational study was undertaken in patients who were satisfying the inclusion criteria and was enrolled into the study conducted for a 6months period in a tertiary care hospital in Bangalore. Results: 150 CKD patients were examined out of which 72% prevalence seen in males compared to females 28%. Dual drug therapy was most preferred combination seen in 48% of the prescriptions. CCB was the most preferred class of drug and least preferred class of drug was ACE. More than 85% deviation from JNC-8 was seen. 20% of mono-therapy was found in adherence to JNC-8. Conclusion: A 15% adherence to JNC-8 guidelines was observed in the treatment indicating need for clinical pharmacist who play vital role in management of CKD by adherence to JNC-8 to ensure safety, efficacy and rationality.
Keywords: Chronic kidney disease, Hypertension, Prescription pattern, JNC-8 guidelines, Compliance, Anti-Hypertensive.
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References
2. Joint National Commission 8(JNC8) guidelines. 2014.
3. Abraham G, Arun KN, Renuka S. Management of hypertension in chronic kidney disease:Consenus statement by an expert panel of Indian nephrologist. Journal of the Association of Physicians of India. February, 2017
4. Neethu J, Yogananda R, Bharathi DR, Varsha P, Sandeep GN. A study on prescription pattern of anti-hypertensive drug in chronic renal failure patients and assessment of medication adherence. International Journal of Pharmceutical Science. 2017; 45(2):72-75.
5. Pavitra RY, Geetha M, Rajeev A, Somshekar HS. Drug Utilisation pattern of anti-hypertensive drug in chronic kidney disease in a tertiary care hospital. IOSR Jornal of Dental and Medicine Science. 2014; 13(11):23-7.
6. Sharminder K, Seema G, Dinesh K, Mohan L, Zahid G. Prescribing pattern Anti-hypertensive Drug in a tertiary care hospital in Jammu-A descriptive study. Clinical Pharmacy. 2012; 17(4):38-41.
7. Kalpana B, Rajesh B, Rubina V, Chhaya G. Drug Utilisation pattern of anti-hypertensive drug in chronic kidney disease stage -5 patient in a tertiary care hospital of central India. International Journal of Basic and Clinical Pharmacology. 2018; 7(7):1411-4.
8. Ashok KM, Manjunath W, Palash P, Thella MC. Study of Prescribing pattern Anti-hypertensive Drug and Evaluation of the Prescription with JNC 8 Guidelines in North Karnataka. Indian Journal of Pharmacy Practice. 2018; 11(4):193-6.
9. Giri RD, Guru PD, Chandrakanth P. Prescribing pattern Anti-hypertensive Drug based on compelling indicators. International Journal of Pharamceutical Science. 2016; 8(2):72-5.
10. Alwyn PS, Ankur CE, Maheswari E, Gurudev KC. Prescribing pattern and cost effectiveness analysis of anti-hypertensive drug in chronic kidney disease patient. European Journal of Pharmaceutical and Medical Research. 2016; 3(1):219-25.
11. Bhanu PB, Basavanna PL. Pattern of anti-hypertensive drug utilisation in chronic kidney disease patient in dialysis unit of tertiary care hospital. International Journal of Biomedical Research. 2015; 6(04):251-4.
12. Sivasakthi R, Sam S, Nityan K, Anna CJ, Venkatanarayanan. Assessment of Prescribing Pattern for Hypertension and Comparison with JNC-8 Guidelines-Proposed intervention by Clinical Pharmacist. J Young Pharm. 2016; 8(2):133-5.
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