Majoon-E-Piyaz: A Potent Unani Formulation for Premature Ejaculation
Surʻat-e-Inzāl (Premature Ejaculation) is the most prevalent male sexual dysfunction affecting 25 - 40% global population of men. It is a universal disorder and is independent of age, social or marital status. It has a significant impact on both- patients and their partners, causing distress, anxiety and relationship difficulties affecting the quality of life. Several aetiologies have been proposed by various researchers which are not evidence-based but speculative. Accordingly the International Society for Sexual Medicine (ISSM) issued treatment guidelines for Premature Ejaculation (PE) recommending Serotonergic Antidepressants (SSRIs) and Local Anaesthetics (LA) for its management in modern medicine. However, these treatments were not actually developed for PE, and have limitations associated with their off-label use. Furthermore, nearly all the recommended drugs have a wider spectrum of adverse effects and serious drug interactions which sometimes could be fatal. On the other hand, centuries old Unani medicine offers a complete line of treatment for Surʻat-e-Inzāl based on traditional knowledge and experience. Unani physicians devised a large number of poly-herbal recipes which are still in vogue. Majoon-e-Piyaz (MP) is one of the compound Unani formulations which are in use for the treatment of premature ejaculation since centuries. This article is an attempt to summarize scientific investigations in support of the claim made by Unani physicians regarding Majoon-e-Piyaz (MP).
Keywords: Surʻat-e-Inzāl, Premature Ejaculation, Majoon-e-Piyaz, Unani Medicine
2. Anonymous. The Unani Pharmacopoeia of India. 1st Edition, Government of India Ministry of AYUSH, New Delhi. To be published by Pharmacopoeia Commission of Indian Medicine & Homeopathy, Ghaziabad. Part-II, Vol. IV (Formulations); (YNM).121-23 p.
3. Anonymous. Physicochemical standards of Unani formulations. Government of India Ministry of Health & Family Welfare. Publisher: Central Council for Research in Unani Medicine, New Delhi. Part-2; (1987).138-40 p.
4. Ghani M.N. Khazain-ul-adviya. Publisher: Central Council for Research in Unani Medicine. Printed by New India Offset Printers, 1231, Churiwalan, Delhi. (2010).Vol. II (37, 457p); Vol. III(113; 148; 200; 231p.); Vol. VI (341; 351p).
5. Ali S.S. Unani Adviya Mufarrada. 5th edition, Qaumi Council Barae Farogh-e-Urdu Zaban, Institutional Area, Jasola, New Delhi. (2010; 87:108, 117, 175, 244, 266.
6. Al-Snafi AE. Traditional uses of Iraqi medicinal plants IOSR Journal of Pharmacy 2018; 8(80:32-95.
7. Khare CP. Indian Medicinal Plants- An illustrated dictionary. Publisher; Springer Science + Business Media, LLC. New York, USA. (2007). 140-41p, 401p.
8. Zakai MF, Nazar H, Usmanghani K, Ayaz S. Study of fertility potential in Oligospermia with herbal dosage form design. Mintage J Pharm & Med Sci; 2012: 1(1):14-16.
9. Jagdale SP, Shimpi S, Chachad D. Pharmacological studies of ‘Salep’. Journal of Herbal Medicine and Toxicology; 2009: 3(1):153-156.
10. Islam MW, Tariq M, Ageel AM, Al-Said MS, Al-Yhya AM. Effect of Salvia haematodes on sexual behaviour of male rats. Journal of Ethnopharmacology. 1991; 33(1-2):67-72.
11. Bansode FW, Rajendran SM, Singh RK. Dose‐dependent effects of ethanol extract of Salvia haematodes Wall roots on reproductive function and copulatory behaviour in male rats aNDROLOGIA 12 March 2014 https://doi.org/10.1111/and.12255
12. Singh B, Sharma A and Ishar MPS. Antianxiety Investigations of Centaurea behen Linn. and Elaeocarpus ganitrus Roxb. Journal of Pharmacy Research 2012, 5(3):1483-1486
13. Saeid JM, Shanoon AK, Marbut MM. Effects of Zingiber officinale. Aqueous Extract on Semen Characteristic and Some Blood Plasma, Semen Plasma Parameters in the Broilers Breeder Male. Int J Poult Sci. 2011; 10 (8):629-633.
14. Ghlissi Z, Atheymen R, Boujbiha MA, Sahnoun Z, Makni Ayedi F, Zeghal K, El Feki A, Hakim A. Antioxidant and androgenic effects of dietary ginger on reproductive function of male diabetic rats. Int J Food SciNutr. 2013; (64):974-978.
15. Al-Katib SM, Al-Khashab EM, Kalo MS, Hamdoon AA. The Antioxidant Effects of Flavonoids and non Flavonoid Part Extracted from Ginger (Zingiber officinale) Roots. Jou Raf Sci. 2009; (20):18-31.
16. Pratap SR, Ritesh J, Rahul M, Prashant T. Antidepressant activity of hydroalcoholic extract of Zingiber officinale. International Research Journal of Pharmacy. 2012; (3):149-151.
17. Banihani SA. Testosterone in Males as Enhanced by Onion (Allium Cepa L.) Biomolecules. 2019 Feb; 9(2):75. Published online 2019 Feb 21. doi: 10.3390/biom9020075 PMCID: PMC6406961. PMID: 30795630
18. Manhal M. Dafaalla, Salah Abdoun , Abdel Wahab Hassan and Omer Fadl Idris. Effects of ethanolic extract of Raphanus sativus seeds on fertility hormone and sperm parameters in male wistar rats. World J. Pharm. Res. 2017; 6 (5):28-36. DOI: 10.20959/wjpr20175-8315
19. Chauhan NS, Sharma V, Dixit VK. Effect of Asteracantha longifolia seeds on the sexual behaviour of male rats. Nat Prod Res. 2011 Sep; 25(15):1423-31.
20. Sharma P, Chandrul K K. Chlorophytum borivilianum (Safed musli): A Vital Herbal Drug Int. J. Pharm. Med. Res. 2017; 5(1):401-411
21. Chauhan NS, Rao ChV and Dixit VK: Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats. Fitoterapia 2007; 78(7-8):530-534.
22. Chauhan NS and Dixit VK: Spermatogenic activity of rhizomes of Curculigo orchioides Gaertn in male rats. International Journal of Applied Research in Natural Products 2008; June-July, 1(2):26-31.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).