Cell Biology in Rheumatoid Arthritis

  • Lukeshwari Sahu Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)
  • S. Prakash Rao Department of Pharmacognogy, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111(Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)
  • Mahendra Verma Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)
  • Akhilesh Kumar Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)
  • Rajendra Sahu Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)
  • Dhanesh Kumar Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)
  • Chandrakant Yadav Department of Pharmaceutics, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111(Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease, which affects about 0.33 to 2.65% of the population. In RA Synovium contain various type of immune cell. In which only one cell population cannot cause rheumatoid arthritis that requires more than one cell population. In normal condition, they act as a switch (active or inactive the cell signaling). It controls cell growth, proliferation or metastasizes. In an autoimmune disorder such as rheumatoid arthritis, the immune system mistakenly attacks and destroys the body's cells and tissues. Mostly cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases, this population can expand to constitute 5-20% or more of all synovial cells. Recent investigations in a murine model have demonstrated that cells can have a critical role in the generation of inflammation within the joint.


Keyword: Cell Biology in rheumatic arthritis; Dendrite cell; T-cell; Mast cell; Fibroblastic cell; Macrophages cell.

Keywords: Cell Biology in rheumatic arthritis, Dendrite cell, T-cell, Mast cell, Fibroblastic cell, Macrophages cell

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Author Biographies

Lukeshwari Sahu, Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

S. Prakash Rao, Department of Pharmacognogy, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111(Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmacognogy, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111(Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Mahendra Verma, Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Akhilesh Kumar, Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Rajendra Sahu, Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Dhanesh Kumar, Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111 (Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Chandrakant Yadav, Department of Pharmaceutics, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111(Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

Department of Pharmaceutics, Columbia Institute of Pharmacy, Tekari, Raipur, (CG), Pin 493111(Affiliated to Chhattisgarh Swami VivekanandaTechnology University (CSVTU)

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Sahu L, Rao SP, Verma M, Kumar A, Sahu R, Kumar D, Yadav C. Cell Biology in Rheumatoid Arthritis. JDDT [Internet]. 15Jun.2020 [cited 2Jul.2020];10(3-s):348-57. Available from: http://jddtonline.info/index.php/jddt/article/view/4113