Formulation of Ramipril Tablets Containing Solid Dispersion Employing Selective Polymers to Enhance Dissolution Rate

  • Inder Kumar School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India
  • Sandeep Verma School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India
  • Amit Chaudhary School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

Abstract

Objective: The present work based on formulation of Ramipril tablets containing solid dispersion employing selective polymers. The objective of the preparation is to prepare the solid dispersion of the Ramipril, which has more responsive value in terms of the dissolution rate.


Method: Solid dispersion complex was prepared with two different carriers PEG 6000 and PVP K30. Nine formulations were developed and each formulation were subjected to pre compression and post compression parameters.


Result and Discussion:  Pre-compression and post compression parameters were studied which had shown good flow property and compiled the standard data. In-vitro dissolution studies shows more than 90 % drug release in phosphate buffer pH 6.8 in 30 min. Out of all formulation F4 showed 92.55±0.67 % drug release with in 30min which was the best result rest of the formulation.


Conclusion: Ramipril tablets were successfully prepared and evaluated. F4 formulation shows the greater dissolution rate in phosphate buffer pH 6.8 as compared to other formulations. When compared with marketed formulation it also shows better results. Therefore, Ramipril solid dispersion tablets enhanced the dissolution rate and can be more efficacious for improving oral bioavailability of Ramipril.


Keywords: Solid dispersion, Ramipril, Solvent Evaporation Technique.

Keywords: Solid dispersion, Ramipril, Solvent Evaporation Technique

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Author Biographies

Inder Kumar, School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

Sandeep Verma, School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

Amit Chaudhary, School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

School of Pharmacy, Abhilashi University, Chailchowk, Mandi, India

References

1. Sekiguchi K. Studies on Absorption of Eutectic Mixture. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man. Chem Pharm Bull. 1961: 866-872.
2. Manogna K, Nagaveni P, Thyagaraju K. Enhancement of solubility of poorly soluble drugs by solid dispersion: An overview. Ind. Journal of Pharmaceutical and Biological Research. 2017; 5:17-23.
3. Fischer, Jnos Ganellin, C Robin. Analogue-based Drug Discovery. John Wiley & amp; Sons. 2006; 469.
4. British national formulary: BNF. Pharmaceutical Press. 2018; 76:172–173.
5. Hilal Dandan R, Goodman Gilmans. The Pharmacological Basis of Therapeutics. McGraw-Hill Education. 2018; 13:26.
6. Frampton JE, Peters DH. Ramipril An updated review of its therapeutic use in essential hypertension and heart failure. Drugs. 1995; 49(3):440–66.
7. Ali J, Khar R, Ahuja A. A textbook of dosage form design. Birla publications Pvt Ltd, Delhi. 3rd edition. 2008; 100-107.
8. Pandey A, Rath B, AK D. Pharmaceutical Preformulation Studies with Special Emphasis on Excipients Compatibility. Chem Inform. 2012; 43(23): 20-5.
9. KP Sampath Kumar, Debjit Bhowmik, Rajnish Kumar Singh. Formulation and evaluation of Ramipril transdermal patch. IAJPR. 2014; 4(4):1850-1856
10. George SJ, Vasudevan DT. Studies on the preparation, characterization and solubility of 2-HP-β-cyclodextrin-Meclizine HCl inclusion complexes. JYP. 2012; 4(4):220-227.
11. Peixiao T, Shanshan Li, Wang L, Yang H, Yan J, Hui L. Inclusion complexes of chlorzoxazone with β- and hydroxypropyl-β-cyclodextrin: Characterization, dissolution,and cytotoxicity. Carbo. Poly 131. 2015:297–305
12. B Venkateswara Reddy, K Navaneetha. Formulation and evaluation of sustain release tablets of Ramipril. Pharmatutor. 2014; 2(7):110-119.
13. Swati CJ, Yashwant TD, Bhanudas SK. Solubility enhancement and formulation of buccal patches of ramipril cyclodextrin complex. Asian J Pharm Clin Res. 2013; 6(2):83-90.
14. Venugopal P, Gnanaprakash K, Kumar B, Gobinath M, Narendra RB. Development of formulation and evaluation of Ramipril porous tablet by sublimation technique. IJB. 2014; 5(4):258-264.
15. Bhusnure OG, Kazi P, Gholve SB, S, Thonte SS, Sangshetti JN. Formulation and Evaluation of Fast Disintegrating Tables of Nifedipine by QbD Approach. IJPPR. 2015; 4(3):198-229.
16. Pradhan R, Tran TH, Choi JY, Choi IS, Choi HG, Yong CS, et al. Development of a rebamipide solid dispersion system with improved dissolution and oral bioavailability. Arch. Pharm. Res. 2014: 1-12.
17. Jumbarathi SK, Chandrasekhara RB, Kavati R, Vanitha PK. Formulation and evaluation of bilayer floating tablets of atorvastatin and ramipril. IAJPS. 2014; 1(2):98-106.
18. Manjil P, Tekade A, Gattani S, Surana S. Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques. Pharm Sci Tech. 2008; 9(4):1262-1269.
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Kumar I, Verma S, Chaudhary A. Formulation of Ramipril Tablets Containing Solid Dispersion Employing Selective Polymers to Enhance Dissolution Rate. JDDT [Internet]. 15Jun.2020 [cited 2Jul.2020];10(3-s):142-9. Available from: http://jddtonline.info/index.php/jddt/article/view/4109