Statistical Retrospective Analysis of Spontaneous Abortions in Sidi Bel Abbes Region

  • Sarah Mellali SESNV Institute, University Center Ahmed ZABANA; Bourmadia, Relizane. Algeria
  • Khadidja Haoud Department of Biology, Faculty of Natural and Life Sciences; Djillali Liabes University, Sidi Bel Abbès-Algeria
  • mohammed el amin Bouguetaia Ouled Mohamed Chlef Hospital, Chlef, Algeria
  • Mustapha Diaf Department of Biology, Faculty of Natural and Life Sciences; Djillali Liabes University, Sidi Bel Abbès-Algeria


Objective: The aim of our study was to identify modifiable risk factors for miscarriage and to estimate the preventable proportion of miscarriages that could be attributed to these risks. Materials and Method: We carried out an epidemiological study of pregnancy loss in the Sidi Bel Abbes region from 2010 to 2015, with a total of 54720 livebirths and 4349 of spontaneous abortions (SA). The risk of spontaneous abortion related to the fetal loss age, maternal age; parity and previous spontaneous abortions was studied. Results: The rate of spontaneous abortions varies between 7% and 9% and appears to remain constant over the six years, with an average incidence of 8%. We also observed a significant increase in the incidence of SA with the increase in maternal age. 77% of SA occurred before 12 weeks of gestation. The peak incidence occurred during the second month of pregnancy, between 6th and 10th, the rate of AS is the highest among primigests. The incidence of SRA in our study is within the range suggested by these different studies, with a SRA rate of 5%. Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. Conclusion: The fact remains that the risk factors remain the same, namely, the increase in maternal age (inducing an increase in chromosomally unbalanced designs) and primigestity.

Keywords: Spontaneous, abortion, epidemiological, study, risk, factors.

Keywords: Spontaneous, abortion, epidemiological, risk, factors


Download data is not yet available.

Author Biographies

Sarah Mellali, SESNV Institute, University Center Ahmed ZABANA; Bourmadia, Relizane. Algeria

SE & SNV Institute, University Center Ahmed ZABANA; Bourmadia, Relizane. Algeria

Khadidja Haoud, Department of Biology, Faculty of Natural and Life Sciences; Djillali Liabes University, Sidi Bel Abbès-Algeria

Department of Biology, Faculty of Natural and Life Sciences; Djillali Liabes University, Sidi Bel Abbès-Algeria

mohammed el amin Bouguetaia, Ouled Mohamed Chlef Hospital, Chlef, Algeria

Ouled Mohamed Chlef Hospital, Chlef, Algeria

Mustapha Diaf, Department of Biology, Faculty of Natural and Life Sciences; Djillali Liabes University, Sidi Bel Abbès-Algeria

Department of Biology, Faculty of Natural and Life Sciences; Djillali Liabes University, Sidi Bel Abbès-Algeria


1. Regan L and Rai R, Epidemiology and the medical causes of miscarriage. Best Practice & Research Clinical Obstetrics & Gynaecology, 2000; 14:839-54. ; DOI: 10.1053/beog.2000.0123
2. Garcia-Enguidanos A, Calle ME, Valero J, Luna S, Dominguez-Rojas V, Risk factors in miscarriage: a review. European Journal of Obstetrics & Gynecology, 2002; 102:111–19. ; DOI: 10.1016/s0301-2115(01)00613-3
3. Savitz DA, Hertz-Picciotto I, Poole C, Olshan AF, Epidemiologic measures of the course and outcome of pregnancy. Epidemiologic Reviews, 2002; 24:91–101. ; DOI: 10.1093/epirev/mxf006
4. NyboAndersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M, Maternal age and fetal loss: population based register linkage study. British Medical Journal, 2000; 320(7251):1708-1712.; DOI: 10.1136/bmj.320.7251.1708
5. Simpson JL, Causes of fetal wastage. Clinical Obstetrics and Gynecology, 2007; 50:10–30. ; DOI:10.1097/GRF.0b013e31802f11f6.
6. Coste J, Job-Spira N and Fernandez H, Risk of factors for spontaneous abortions: a case control study in France. Human Reproduction, 1991; 6:1332-1337. . DOI: 10.1093/oxfordjournals.humrep.a137535.
7. Fretts RC, Shmittdil J, Mclean FH et al., Increase maternal age and the risk of fetal death. The New England Journal of Medicine, 1995; 333:953-957. DOI:10.1056/NEJM199510123331501.
8. Osborn JF, Cattaruzza MS and Spinelli A, Risk of spontaneous abortion in Italy, 1978-1995 and the effect of maternal age, gravidity, marital status and education. American Journal of Epidemiology, 2000; 151:312-313. DOI:10.1093/oxfordjournals.aje.a010128
9. Naylor AF and Warburton D, Sequential analysis of spontaneous abortion. In: collaborative study data show that gravidity determines a very substantial rise in risk. Fertility Sterility, 1979; 31:282–286. PMID: 437160
10. Christiansen O, Epidemiological, immunogenetic and immunotherapeutic aspects of unexplained recurrent miscarriage. Danish medical bulletin, 1997; 44:396–424. PMID: 9377902
11. Kline J. Stein Z, Susser M. Conception to birth—epidemiology of prenatal development. Monographs in Epidemiology and Biostatistics. Oxford, Oxford University Press, 1989.
12. Chard T. Frequency of implantation and early pregnancy loss in natural cycles. Clinical Obstetrics and Gynecology, 1991; 5:179–89. DOI: 10.1016/s0950-3552(05)80077-x.
13. Rai R and Regan L, Recurrent miscarriage. Lancet, 2006; 368:601–11. DOI: 10.1016/S0140-6736(06)69204-0
14. Merviel P, Lanta S, Allier G, Gagneur O, Najas S. et al. Avortements spontanés à répétition. EMC-Gynécologie Obstétrique, 2005; 2:278–296. Doi : 10.1016/S0246-1064(13)59740-4.
15. Jauniaux E and Burton GJ, Pathophysiology of Histological Changes in Early Pregnancy Loss. Placenta, 2005; 26:114-123. 10.1016/j.placenta.2004.05.011
16. Glinianaia SV, Rankin J, Bell R, Pearce MS, Parker L, Temporal changes in the distribution of population risk factors attenuate the reduction in perinatal mortality. Journal of Clinical Epidemiology, 2005; 58(12):1299-1307.
17. Stirrat GM. Recurrent miscarriage. Lancet, 2007; 336:673–75. DOI: 10.1016/0140-6736(90)92159-f.
18. Sullivan AE, Silver RM, LaCoursiere DY, Porter TF, Branch DW:Recurrent fetal aneuploidy and recurrent miscarriage. Obstetetrical Gynecology, 2004; 104:784-788. DOI: 10.1097/01.AOG.0000137832.86727.e2
19. Ventura SJ, Taffel SM and Mosher WD, Estimates of pregnancies and pregnancy rate for the United-States: 1976-1985. American Journal of Public Health, 1988; 78:506-511. DOI: 10.2105/ajph.78.5.506
20. Guyer B, Hoyert DL, Martin JA et al. Annual summary of vital statistics-1998-. Pediatrics, 1999; 104:1229-1246.; DOI: 10.1542/peds.104.6.1229.
21. Cano F, Simon C, Remohi J, Pellicer A, Effect of ageing on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity. Fertility and Sterility, 1995; 64:584–589.; DOI:10.1016/s0015-0282(16)57797-8
22. Dominguez V, Calle E, Ortega P et al. Adjusting risk factors in spontaneous abortion by multiple logistic regressions. European Journal of Epidemiology, 1991; 78:171-174.; DOI: 10.1007/bf00237362
23. Brigham S, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurring miscarriage. Human Reproduction, 1999; 14:2868–2871.; DOI:10.1093/humrep/14.11.2868
24. Bricker L and Farquharson RG, Types of pregnancy loss in recurrent miscarriage: implications for research and clinical practice. Human Reproduction, 2002; 17:1345–1350.; DOI:10.1093/humrep/17.5.1345
25. Ugwumadu A, Manyonda I, Reid F, Hay P, Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomized controlled trial. Lancet, 2003; 361:983–988.; DOI :10.1016/S0140-6736(03)12823-1
26. Mattar R and Mendes ET. Abortion. In: Camano L et al. (eds) Obstetrics, 1st edn. Manole, São Paulo, 2002.
27. Bjørn AM, Nørgaard M, Hundborg HH, Nohr EA, Ehrenstein V, Use of prescribed drugs among primiparous women: an 11-year population-based study in Denmark. Clinical Epidemiology, 2011; 3:149-56. DOI:10.2147/CLEP.S17747
28. Czeizel A, Bognar Z and Rocckenbauer M, Some epidemiological data on spontaneous abortion in Hungary, 1971-80. Journal of Epidemiology and Community Health, 1984; 38:143-148. DOI:10.1016/0753-3322(91)90025-o.
29. Raymond EG, Cnattingius S, Kiely JL, Effects of maternal age, parity, and smoking on the risk of stillbirth. British Journal of Obstetrics and Gynaecology, 1994; 101(4):301. DOI:10.1111/j.1471-0528.1994.tb13614.x
30. Royal College of Obstetricians and Gynecologists. The management of recurrent miscarriage. Guideline no. 17. London: Royal College of Obstetricians and Gynecologists, 1998.
31. The American College of Obstetricians and Gynecologists. Bylaws Obstetrics & Gynecology: May 2001; 98(1):186–192.
32. Stephenson MD, Awartani KA, Robinson WP, Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a casecontrol study. Human Reproduction, 2002; 17:446–510.
33. Elghezal H, Hidar S, Mougou S, Khairi H, Saad A, Prevalence of chromosomal abnormalities in couples with recurrent miscarriage. Fertility Sterility, 2007; 88:721–3. DOI:10.1016/j.fertnstert.2006.11.160
34. Regan L. Recurrent miscarriage. British Medical Journal, 1991; 302:543–44. 10.1136/bmj.302.6776.543.
35. Carrington B, Rai R, Regan L, Polycystic ovaries, insulin resistance, hypofibrinolysis and recurrent miscarriage. Journal of the Society for Gynecologic Investigation, 2005; 12: 20.
36. Hogge WA, Byrnes AL, Lanasa MC, Surti U, The clinical use of karyotyping spontaneous abortions. American Journal of Obstetrics and Gynecology, 2003; 189:397–400. DOI:10.1067/s0002-9378(03)00700-2.
37. Coulam CB, Epidemiology of recurrent spontaneous abortion. American Society for Reproductive Immunology, 1991; 26:23–7. DOI: 10.1111/j.1600-0897.1991.tb00697.x
38. Scott JR, Rote NS, and Branch DW, Immunologic aspects of recurrent abortion and fetal death. Obstetrics & Gynecology, 1987; 70:645–656. PMID: 3114693.
39. Ogasawara M, Aoki K, Okada S, Suzomori K, Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertility Sterility, 2000; 73:300–4. DOI:10.1016/s0015-0282(99)00495-1.
30 Views | 19 Downloads
How to Cite
Mellali S, Haoud K, Bouguetaia mohammed el amin, Diaf M. Statistical Retrospective Analysis of Spontaneous Abortions in Sidi Bel Abbes Region. JDDT [Internet]. 15May2020 [cited 5Jun.2020];10(3):202-6. Available from: