Formulation Development and Evaluation of Fast Dissolving Oral Film of Midodrine Hydrochloride

  • Aashish Marskole RKDF School of Pharmaceutical Science, Bhopal (M. P.), India
  • Sailesh Kumar Ghatuary RKDF School of Pharmaceutical Science, Bhopal (M. P.), India
  • Abhishek Parwari RKDF School of Pharmaceutical Science, Bhopal (M. P.), India
  • Geeta Parkhe Scan Research Laboratory, Bhopal (M.P.), India

Abstract

Oral fast dissolving midodrine hydrochloride films prepared by solvent casting method, PEG 400 was the selected plasticizers, incorporating superdisintegrants such as croscarmellose sodium (CCS) and sodium starch glycolate (SSG) to achieve the goal. Drug content, weight variability, film thickness, disintegration time, endurance, percentage of moisture content, and in vitro dissolution tests were analyzed for the prepared films. In all formulations, the tensile strength value was found from 0.965±0.045 and 1.256±0.032 and the folding capacity was over 100. The assay values ranged from 97.98±0.25 to 99.89±0.36 percent for all formulations. The disintegration time was ranging between 55±9 to 120±6 sec, the minimum time for disintegration was found in formulation F5 (55±9). The prepared F5 formulation shows greater release of the drug (99.25±0.41 percent) within 15 min relative to other formulations. As the drug having low solubility, fast disintegration may leads to more drug availability for dissolution, resulting in faster absorption in systemic circulation increased systemic availability of drug leads to quick onset of action which is prerequisite for hypertension.


Keywords: Midodrine hydrochloride, Fast dissolving films, Solvent casting method, Superdisintegrants.

Keywords: Midodrine hydrochloride,, Fast dissolving films, Solvent casting method, Superdisintegrants

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Author Biographies

Aashish Marskole, RKDF School of Pharmaceutical Science, Bhopal (M. P.), India

RKDF School of Pharmaceutical Science, Bhopal (M. P.), India

Sailesh Kumar Ghatuary, RKDF School of Pharmaceutical Science, Bhopal (M. P.), India

RKDF School of Pharmaceutical Science, Bhopal (M. P.), India

Abhishek Parwari, RKDF School of Pharmaceutical Science, Bhopal (M. P.), India

RKDF School of Pharmaceutical Science, Bhopal (M. P.), India

Geeta Parkhe, Scan Research Laboratory, Bhopal (M.P.), India

Scan Research Laboratory, Bhopal (M.P.), India

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Marskole A, Ghatuary SK, Parwari A, Parkhe G. Formulation Development and Evaluation of Fast Dissolving Oral Film of Midodrine Hydrochloride. JDDT [Internet]. 15Jun.2020 [cited 2Jul.2020];10(3-s):107-10. Available from: http://jddtonline.info/index.php/jddt/article/view/4099