Synthesis and Physicochemical Characterization of Banana Starch Tartrate and its Application as Disintegrant in Telmisartan Tablets

  • Abhijeet Vishnu Puri Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India
  • Prakash D. Khandagale Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India
  • Ankita U. Tiwari Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India
  • Rekhadevi H. Chaudhary Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India
  • Sonam B. Kartan Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Abstract

The present investigation was aimed to isolate banana starch (BS), synthesis of banana starch tartrate (BST), characterization, and application as a novel disintegrant in telmisartan tablets. Starch tartrate was synthesized by the esterification process by the treatment of tartaric acid on the backbone of the BS. Synthesized BST was found to be fine, slightly free-flowing and crystalline powder. The synthesized BST was subjected to Scanning Electron Microscopy (SEM) and micrometric evaluation. Flow properties of BS and BST were determined as an angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio, etc. BST exhibited good swelling properties and showed no gelling at 100°C but it was transformed into a clear solution. Fourier transform infrared spectra (FTIR) did not show the presence of any significant interaction between BST and Telmisartan(T). The direct compression technique was employed in formulating telmisartan tablets using BST sodium starch glycolate and crospovidone as a disintegrant.  Tablets were comparatively evaluated for weight variation, thickness, hardness, friability, and disintegration. The tablets formulated using BS and BST passed prescribed evaluation tests for weight variation, friability, hardness, and thickness. The tablets formulated using BST as disintegrant gave optimum disintegration compared to those tablets containing sodium starch glycolate and crospovidone sodium super disintegrants. Evaluations indicated that synthesized BST shows qualitatively and quantitatively good disintegration characteristics in comparison to super disintegrants in telmisartan tablet formulation. These results suggest that the synthesized BST could be used as a novel semi-synthetic disintegrant in dispersible tablet formulations.


Keywords: Banana Starch, Banana Starch tartrate, Telmisartan, Superdisintegrant

Keywords: Banana Starch tartrate, Telmisartan, Superdisintegrant

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Author Biographies

Abhijeet Vishnu Puri, Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Prakash D. Khandagale, Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Ankita U. Tiwari, Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Rekhadevi H. Chaudhary, Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Sonam B. Kartan, Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar-401404 (M. S) India

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Puri A, Khandagale PD, Tiwari AU, Chaudhary RH, Kartan SB. Synthesis and Physicochemical Characterization of Banana Starch Tartrate and its Application as Disintegrant in Telmisartan Tablets. JDDT [Internet]. 15May2020 [cited 24Sep.2020];10(3):65-2. Available from: http://jddtonline.info/index.php/jddt/article/view/4089