Role of Micro Emulsion Based In-Situ Gelling System of Fluoroquinolone for Treatment of Posterior Segment Eye Diseases (PSED)

  • Eram Fatima Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India
  • Dr. Vivek Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Abstract

The in situ drug delivery system and colloidal formulation like micro emulsion has potential to use in ocular delivery. Micro emulsion provides better permeation of drug through the membrane and provides improved bioavailability. The in situ drug delivery system decreases pre-corneal drainage, increase the contact time of formulation with eye and prolong the release in ocular tissues. Again, in situ gelling system has advantage of delivering accurate and reproducible quantities each time, against any already gelled formulations. To combine the benefits of these two dosage forms, micro emulsion based in situ gelling system can be developed as a novel vehicle for ophthalmic drug delivery. Endophthalmitis is an infection of intraocular fluids like vitreous humor and ocular tissues. To combat the disease, the formulation which provides sufficient concentration in posterior segment eye diseases (PSED) is required.


Keywords: Posterior segment eye diseases, micro emulsion, drug delivery system, ocular, formulation.

Keywords: Posterior segment eye diseases, microemulsion, drug delivery system

Downloads

Download data is not yet available.

Author Biographies

Eram Fatima, Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Dr. Vivek, Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

References

1. Pijl BJ, Theelen T, Tilanus MA, Acute Endophthalmitis After Cataract Surgery: 250 Consecutive Cases Treated at a Tertiary Referral Center in the Netherlands. American Journal of Ophthalmologist, 2010; 149:482-7.
2. Kresloff MS, Castellarin AA, Zarbin MA. 'Endophthalmitis', Survey of ophthalmology, 1998; 43(6):193-224.
3. Greenwald MJ, Principles and Practice of Pediatric Infectious Diseases. 3rd edition: Churchill Livingstone-An Imprint of Elsevier; 2008.
4. Hariprasad SM, Blinder KJ, Shah GK, et al. Determination of Vitreous and Aqueous Concentration of Topically Administered Moxifloxacin 0.5% in Humans. Investigative Ophthalmology & Visual Science, 2004; 45:525.
5. Vidyashankar B, Arora S, Singal R, et al. Medical Treatment of Endophthalmitis. Journal of the Bombay Ophthalmologist’s Association, 2001; 11:47-50.
6. Raichand M, Endophthalmitis: Diagnosis and management. Indian Journal of Ophthalmology, 1982; 30(6):635-40.
7. Mah FS, The fourth-generation fluoroquinolones: New topical agents in the war on ocular bacterial infections. Current Opinion in Ophthalmology, 2004; 15(4):316-20.
8. Gardner S. The Evolution of Modern Fluoroquinolones, Advanced Ocular Care, 2010; (4).
9. Ogura Y, Drug delivery to the posterior segments of the eye. Advanced Drug Delivery Reviews, 2001; 52:1-3.
10. Jacquin C, Nasica X, Guillard D, et al, Intravitreal treatment of endophthalmitis. Méd Mal Infect- France, 2001; 31:493-97.
11. Armaly MF, Rao KR. The effect of pilocarpine Ocusert with different release rates on ocular pressure. Investigative Ophthalmology. 1973; 12:491-96.
12. Cordonnier M, The treatment of dry eye with Lacrisert. Bull Soc Belge Ophtalmol, 1984; 212:65-9.
13. Del Amo EM, Urtti A, Current and future ophthalmic drug delivery system- A shift to the posterior segment. Drug Discovery Today, 2008; 13(2).
14. Rupenthal ID, Alany RG, Pharmaceutical manufacturing handbook - Production and processes. Wiley-Interscience, 2008.
15. Jarvinen K, Jarvinen T, Ocular absorption following topical delivery. Advanced Drug Delivery Reviews, 1995; 16:3-19.
16. Worakul N, Robinson JR, Ocular pharmacokinetics/ pharmacodynamics: Review. European Journal of Pharmaceutics and Biopharmaceutics, 1997; 44(1627):71-83.
17. Vellonen KS, Mannermaa E, Urtti A, Drug transport in corneal epithelium and blood–retina barrier: Emerging role of transporters in ocular pharmacokinetics. Advanced Drug Delivery Reviews, 2006; 58:1136-1163.
18. Macha S, Hughes PM, Mitra AK, Ophthalmic Drug Delivery Systems, 2nd edition, Marcel Dekker, 2003.
19. Huang AJW, Tseng SCG, Kenyon KR, Paracellular permeability of corneal and conjunctival epithelia. Investigative Ophthalmology and Visual Science, 1989; 30(4):684-9.
20. Greaves JL. Wilson CG. Treatment of diseases of the eye with mucoadhesive delivery systems. Advanced drug delivery review, 1993; 11(3): 349-383.
21. Ahmed I, Patton TF. Importance of the noncorneal absorption route in topical ophthalmic drug delivery. Investigative Ophthalmology and Visual Science, 1985; 26(4):584-7.
22. Urtti A, Challenges and obstacles of ocular pharmacokinetics and drug delivery. Advanced Drug Delivery Reviews, 2006; 58:1131-1135.
23. Lee VH, New directions in the optimization of ocular drug delivery. Journal of Ocular Pharmacology, 1990; 6(2):157-64.
24. Shinoda K, Lindman B, Organised surfactant systems: microemulsions, Langmuir, 1987; 3:135–49.
25. Sushama T, Adnan A, Farhan JA, Microemulsion: A Novel Approach to Enhanced Drug Delivery. Recent Patents on Drug Delivery & Formulation, 2008; 2:238-57.
26. Anna RS, Joanna W, Microemulsions as Potential Ocular Drug Delivery Systems: Phase Diagrams and Physical Properties.
27. Sumedha N, Chandrakant L, Current Trends in Novel Drug Delivery An OTC Perspective. Pharma Times, 2010; 42:17-23.
28. Vandamme TF, Microemulsions as ocular drug delivery systems: recent developments and future challenges. Progress in Retinal and Eye Research, 2002; 21: 15-34.
29. Kumar K, Senthil D, SaravananR, Microemulsions as Carrier for Novel Drug Delivery: A Review. International Journal of Pharmaceutical Sciences Review and Research, 2011; 10:37-45.
30. Peltola S, Saarinen P, Kiesvaara J, Microemulsions for topical delivery of estradiol, Int. J. Pharm. 2003; 254:99–107
31. Huabing C, Xueling C, Danrong D, Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. International Journal of Pharmaceutics, 2006; 351: 52-58
Statistics
29 Views | 24 Downloads
How to Cite
1.
Fatima E, Vivek D. Role of Micro Emulsion Based In-Situ Gelling System of Fluoroquinolone for Treatment of Posterior Segment Eye Diseases (PSED). JDDT [Internet]. 15May2020 [cited 1Jun.2020];10(3):265-72. Available from: http://jddtonline.info/index.php/jddt/article/view/4079