Liquisolid Technology: Preparation, Characterization and Applications

  • Ashish Prakash Gorle Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405 India
  • Shubham Sunil Chopade Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405 India


With the advent of high throughput screening, drugs are emerging to be more lipophilic and less hydrophilic. Liquisolid Technology aims at solubility enhancement of such entities via cosolvency concept in a relatively minimalistic setup where there is no need of sophisticated machinery and is cost effective. It involves constituting a drug into molecular dispersion via a non-volatile solvent and then transforming it into a dry looking, free flowing compressible powder. This article aims at mapping Liquisolid Technology where its preparation techniques and potential applications are reviewed. An overview of the performance of Liquisolid in areas of dissolution enhancement, zero order release, photostability enhancement, liquipellets and its role in natural product formulations is recorded for a number of drugs.

Keywords: Liquisolid, Dissolution Enhancement, Flowability, Compressibility, Cosolvency

Keywords: Liquisolid, Dissolution Enhancement, Flowability, Compressibility, Cosolvency


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Author Biographies

Ashish Prakash Gorle, Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405 India

Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405 India

Shubham Sunil Chopade, Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405 India

Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405 India


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Gorle AP, Chopade SS. Liquisolid Technology: Preparation, Characterization and Applications. JDDT [Internet]. 15Jun.2020 [cited 2Jul.2020];10(3-s):295-07. Available from: