THE The Effect of Green Tea Infusion (Camellia sinensis) on Histopathology of White Rat (Rattus norvegicus) Liver Sprague dawley Strain Induced by Ethanol

  • Muhartono Muhartono Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia
  • Nabilah Amirah Salsabila Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia
  • Putu Ristyaning Ayu Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

Abstract

Aims: This research aims to determine the effect of green tea infusion (Camellia sinensis) on the hitopathology of white rat liver induced by ethanol.


Method: This study used 30 rats divided into 5 groups as follow negative control group (K1) given aquades, positive control group (K2) given 20% 2 mL/day peroral, treatment group 1, 2, 3 (P1, P2, P3) given 20% ethanol 2 mL/day peroral followed by green tea infusion with doses 0,375 g/day, 0,75 g/day, and 1,5 g/day single dose per oral for 14 days. The the liver of the rat is taken for microscopic examination. The mean Manja Roenigk scores obtained were K1=1,16, K2=3,36, P1=2,8, P2=2,68, and P3=2,56. Data were tested with the Kruskal-wallis test followed by Mann whitney’s post hoc test.


Results:  The results showed a significant mean difference between positive group (K2) and the treatment group P1, P2, and P3. There is no significant mean difference between P1-P2, P1-P3, and P2-P3 which means giving green tea infusion (Cameliia sinensis) in P2 and P3 gave almost the same effect as P1.


Conclusion: There is an effect of giving green tea infusion (Camellia sinensis) to the histopathology of white rat liver induced by ethanol.


Keywords: antioxidants, ethanol, green tea infusion, liver histopathology.

Keywords: antioxidants, ethanol, green tea infusion, liver histopathology

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Author Biographies

Muhartono Muhartono, Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

Nabilah Amirah Salsabila, Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

Putu Ristyaning Ayu, Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

Department of Pathology, Medical Faculty Lampung University, Lampung, Indonesia

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Muhartono M, Salsabila N, Ayu P. THE The Effect of Green Tea Infusion (Camellia sinensis) on Histopathology of White Rat (Rattus norvegicus) Liver Sprague dawley Strain Induced by Ethanol. JDDT [Internet]. 15Apr.2020 [cited 18Aug.2022];10(2-s):90-3. Available from: http://jddtonline.info/index.php/jddt/article/view/4036