Nasal In Situ Gel: Novel Approach for Nasal Drug Delivery

  • Anjali Sunil Sabale Research scholar
  • Abhijeet D Kulkarni
  • Ajay Sunil Sabale


Nasal delivery is an alternative to oral or parenteral administration due to certain limitations such as absorption of the drug, drug targeting to particular organs can cause a problem for administration through oral route.  The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system. Also, lag time related to oral drug delivery is reduces by this route and offers noninvasiveness, self-medication, patient comfort, and patient compliance. Extend drug delivery can be attained by different new dosage forms like in situ gel. In situ formulations are drug delivery systems. The in-situ gelling system is a process in which the solution forms of a gel before administration in the body, but once administrated, it undergoes gelation in-situ, to form a gel. In situ gelling system becomes very popular nowadays because of their several advantages over conventional drug delivery systems like a sustained and prolonged release of a drug, reduced Frequency of administration, improved patient compliance and comfort. Approaches towards the various formulation of in-situ gel concerning temperature, pH, and physicochemical conditions. The in situ gel-forming polymeric formulations offer several advantages like sustained and prolonged action reduced Frequency of administration, in comparison to conventional drug delivery systems.  From a manufacturing point of view, the production of such systems is less complex and thus lowers the investment and manufacturing cost. Various evaluation parameters are considered during the preparation of In-Situ gel.

Keywords: Nasal Drug Delivery, In Situ gel, gelation, polymers, etc

Keywords: Nasal Drug Delivery, In Situ gel, gelation, polymers


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How to Cite
Sabale A, Kulkarni A, Sabale A. Nasal In Situ Gel: Novel Approach for Nasal Drug Delivery. JDDT [Internet]. 15Apr.2020 [cited 30Nov.2020];10(2-s):183-97. Available from: