DEVELOPMENT AND CHARACTERIZATION OF SRM MICROSPHERES OF REPAGLINIDE

  • Anish Kumar Gupta Micro Labs ltd, Baddi (H.P.), INDIA
  • Sunil K Garg National lnstitute of Pharmaceutical Education and Research (NIPER), Export Promotion Industrial Park (EPIP) Zandaha Road, Hajipur, Vaishali 844101
  • S K Pal Micro Labs ltd, Baddi (H.P.), INDIA
  • M Saxena Micro Labs ltd, Baddi (H.P.), INDIA
  • A Sharma Micro Labs ltd, Baddi (H.P.), INDIA

Abstract

The aim of current work to develop and evaluate sustained release mucoadhesive (SRM) microspheres of Repaglinide using emulsification solvent evaporation technique. Effects of formulation variables i.e. polymer concentration and phase volume ratio on particle size, % mucoadhesion and drug release were investigated in this study. Scanning electron microscopy of microspheres with maximum drug content (Formulation CH1:8) demonstrated smooth surface spherical particles with mean diameter of 64.78 ± 3.26 μm. The mean Particle size, % drug loading and mucoadhesion were found to vary by changing the formulation variables. Microspheres size was significantly increased as increasing the polymer concentration in the aqueous phase while size of microspheres decrease as increase in volume of continuous phase. Decrease in size of microspheres leads to decrease in mucoadhesion time, % drug loading and faster the drug release. It can be concluded that the present mucoadhesive microspheres can be an ideal system to deliver the Repaglinide in sustained release manner for management of Type II Diabetes Mellitus.

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Author Biographies

Anish Kumar Gupta, Micro Labs ltd, Baddi (H.P.), INDIA

Micro Labs ltd, Baddi (H.P.), INDIA


Sunil K Garg, National lnstitute of Pharmaceutical Education and Research (NIPER), Export Promotion Industrial Park (EPIP) Zandaha Road, Hajipur, Vaishali 844101
National lnstitute of Pharmaceutical Education and Research (NIPER),Export Promotion Industrial Park (EPIP)
Zandaha Road, Hajipur,
Vaishali 844101
S K Pal, Micro Labs ltd, Baddi (H.P.), INDIA

Micro Labs ltd, Baddi (H.P.), INDIA

M Saxena, Micro Labs ltd, Baddi (H.P.), INDIA

Micro Labs ltd, Baddi (H.P.), INDIA

A Sharma, Micro Labs ltd, Baddi (H.P.), INDIA

Micro Labs ltd, Baddi (H.P.), INDIA

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How to Cite
Gupta, A., Garg, S., Pal, S., Saxena, M., & Sharma, A. (2011). DEVELOPMENT AND CHARACTERIZATION OF SRM MICROSPHERES OF REPAGLINIDE. Journal of Drug Delivery and Therapeutics, 1(1). https://doi.org/10.22270/jddt.v1i1.4