Comparative Study of Chitosan and Carboxy Methyl Chitosan Nanoparticles in Mefenamic Acid Drug Delivery

  • Parankusham Vedavahini University College of technology, Osmania University, Hyderabad, India
  • Chintha Sailu University College of technology, Osmania University, Hyderabad, India

Abstract

Nanoparticle based technologies improve the efficiency and speed of already existing processes.The larger size materials and reagents which are in reactive form, can be nanosized to give efficient output. Chitosan and the carboxy methyl chitosan nanoparticles were prepared by using solvent evaporation nanoprecpitation method, loaded with mefenamic acid, (anthranilic acid derivative) a poorly aqueous soluble drug. Mefenamic acid, if used as conventional dosage form, duration of action was 6 hours; when the drug loaded into Chitosan and the carboxy methyl chitosan nanoparticles the drug release profile was up to 26hrs. The particle size, entrapment efficiency, poly dispersity index, drug loading, drug release profiles of mefenamic acid were compared for both nanoparticles and it was observed that carboxy methyl chitosan nanoparticles released mefenamic acid more effectively than chitosan nanoparticles.


Keywords: Nanoparticles, Chitosan, Carboxy methyl chitosan, Mefenamic acid

Keywords: Nanoparticles, Chitosan, Mefenamic acid

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Author Biographies

Parankusham Vedavahini, University College of technology, Osmania University, Hyderabad, India

University College of technology, Osmania University, Hyderabad, India

Chintha Sailu, University College of technology, Osmania University, Hyderabad, India

University College of technology, Osmania University, Hyderabad, India

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Vedavahini P, Sailu C. Comparative Study of Chitosan and Carboxy Methyl Chitosan Nanoparticles in Mefenamic Acid Drug Delivery. JDDT [Internet]. 15May2020 [cited 1Jun.2020];10(3):83-6. Available from: http://jddtonline.info/index.php/jddt/article/view/3980