Formulation, Development and Evaluation of Fast Dissolving Oral Film of a Selective Serotonin-Reuptake Inhibitor (SSRIS) Escitalopram Oxalate
The purpose of this research was to develop fast dissolving oral film of Escitalopram oxalate. Fast dissolving oral film offers a solution for paediatrics, geriatrics; psychiatric or mentally ill people and those have difficulty in swallowing tablets/capsules resulting in improved patient compliance. Selective serotonin reuptake inhibitors (SSRIs), which are broad spectrum antidepressants that are effective for major depressive disorder and several anxiety disorders. Escitalopram Oxalate is highly selective, more effective and better than other SSRIs. The prepared formulations were evaluated for Thickness, Weight uniformity, Folding Endurance, Percentage of Moisture Content, Drug Content Analysis, Disintegrating time and In vitro dissolution study. Stability studies were carried out with optimized formulation F5 which was stored for a period of one, two and three months at 40±2oC temperature and 75±5% relative humidity for a period 3 months. Thus it can be concluded that Escitalopram oxalate fast dissolving films could be commercially exploited for the treatment of panic disorder using Escitalopram oxalate with merits of faster onset of action, avoidance of extensive first pass metabolism, low dosage regimen, enhanced bioavailability and improved patient compliance.
Keywords: Escitalopram oxalate, Fast dissolving oral film, Evaluation
2. Baldessarini RJ. Drugs and the treatment of psychiatric disorders: Depression and anxiety disorders. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed. London: McGraw-Hill. 2001; 457.
3. Chand P, Gnanarajan G, Kumar G, Kothiyal P. Formulation and evaluation of nasal in-situ gel of escitalopram oxalate for treatment of depression. Eur J Biomed Pharm Sci. 2016; 3(8): 185-201.
4. Figueroa LS, Bhakay A, Jackeline I, Rozo J, Pandya N, Romanach RJ, et al. Preparation and characterization of hydroxyl propyl methyl cellulose films containing stable BCS class II drug nanoparticles for pharmaceutical applications. Int J Pharm. 2012; 423:496-508.
5. Chaudhary H, Gauri S, Rathee P, Kumar V. Development and optimization of fast dissolving oro-dispersible films of Granisetron HCl using box-behnken statistical design. Bull Faculty Pharm 2013; 51:193-201.
6. Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Development and characterization of pharmacokinetic parameters of fast dissolving films containing levocetirizine. Sci Pharm. 2012; 80:779-87.
7. Cilurzo F, Cupone IE, Minghetti P, Buratti S, Selmin F, Gennari CG, et al. Nicotine fast dissolving films made of maltodextrins: A feasibility study. AAPS J. 2010; 11:1511-7.
8. Narware H, Malviya K, Sirohi B, Omray LK. RP-HPLC and UV spectrophotometric methods for estimation of ticagrelor in pharmaceutical formulations. Asian Journal of Pharmaceutical Education and Research. 2018; 7(4): 94-106.
9. Singh J, Choubey N, Sharma HK, Budholiya P, Parkhe G. Journal of Medical Pharmaceutical and Allied Sciences. 2019; 8(5): 2347-2358.
10. Khan MA, Pandey GK, Joshi A, Dubey BK, Jain AK, Jain P. Formulation development and evaluation of fast dissolving oral film of a lipid-lowering drug. Asian Journal of Pharmaceutical Education and Research. 2019; 8(1): 12-22.
11. Sahu G, Patel M, Jain P, Pandey A. Formulation and evaluation of fast dissolving oral films of trazodone hydrochloride. Asian Journal of Pharmaceutical Education and Research. 2018; 7(4):30-38.
12. Patle B, Jain V, Shende S, Jain PK. Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate. JDDT. 2019; 9(4):445-50.
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