Synthesis and characterization of some novel coumarin based various 2-aryl-pyrido [3,2-c] coumarins

  • Mahesh K. Pandya Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)
  • Tapan H. Parekh Department of Chemistry Shree P. M. Patel Instititue of Post Graduate Studies & Research in applied Science, Affiliated to Sardar Patel University, Vallabh Vidyanagar (Anand), Gujarat, (INDIA)
  • Mehulsinh R. Chhasatia Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)
  • Nileshkumar D. Vala Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

Abstract

A survey of the literature reveals that the number of coumarin derivatives having heterocyclic moieties either as substituent groups or fused with parent coumarin nucleus possesses a variety of functions and are widely used in drugs and dyes. Because of this wide utility, the synthesis of coumarin has remained a subject of active interest. Looking at the importance of these heterocoumarins and with a view to exploring new methods of their synthesis, the present work was undertaken and  this synthesis deals with  various 2-aryl-pyrido [3,2-c] coumarins. The compounds have been synthesized by reacting Mannich bases of various 4-hydroxy coumarins with pyridinium salts of various aroyl methyl bromides in the presence of ammonium acetate and acetic acid. All the compounds synthesized have been characterized by analytical and spectral data.


Keywords: Pyrido, Coumarins, Krohanke’s reaction.

Keywords: Pyrido, Coumarins, Krohanke’s reaction

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Author Biographies

Mahesh K. Pandya, Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

Tapan H. Parekh, Department of Chemistry Shree P. M. Patel Instititue of Post Graduate Studies & Research in applied Science, Affiliated to Sardar Patel University, Vallabh Vidyanagar (Anand), Gujarat, (INDIA)

Department of Chemistry Shree P. M. Patel Instititue of Post Graduate Studies & Research in applied Science, Affiliated to Sardar Patel University, Vallabh Vidyanagar (Anand),  Gujarat, (INDIA)

Mehulsinh R. Chhasatia, Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

Nileshkumar D. Vala, Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

Department of Chemistry Sardar Patel University, Vallabh Vidyanagar, Gujarat, (INDIA)

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Pandya MK, Parekh TH, Chhasatia MR, Vala ND. Synthesis and characterization of some novel coumarin based various 2-aryl-pyrido [3,2-c] coumarins. JDDT [Internet]. 15Mar.2020 [cited 8Jul.2020];10(2):158-63. Available from: http://jddtonline.info/index.php/jddt/article/view/3933