Preparation and Evaluation of Sulfacetamide Sodium Ocusert for Controlled Drug Delivery

  • Manisha A Nagpal Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India
  • Karan Sharma Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India
  • Nupur Anand Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India
  • Disha Singh Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India
  • Ravi Dhawan Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, Punjab, India
  • Md. Rageeb Md. Usman Department of Pharmacognosy, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India
  • Navneet Nagpal Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Abstract

The intent of this research was to formulate and evaluate controlled release ocusert of sulfacetamide sodium for the treatment of bacterial conjunctivitis. Ocusert is a sterile preparation having drug as dispersion or as solution in the polymeric base. Prepared Ocuserts were formulated using hydroxyl propyl methyl cellulose K-15 and Ethyl cellulose as polymers at various concentrations and combinations. Polymeric Films were prepared by mercury casting method using different ratios of polymers. Selected physiochemical properties such as thickness, weight, percentage moisture absorption, and in-vitro release and sterility studies of sulfacetamide sodium ocusert were studied and reported that prepared ocusert resolved the problems of poor bioavailability, frequent dosing and wastage of active ingredient.


Keywords: Hydroxypropyl methyl cellulose K-15, ocusert, sulfacetamide sodium

Keywords: Hydroxypropyl methyl cellulose K-15, ocusert, sulfacetamide sodium

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Author Biographies

Manisha A Nagpal, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Karan Sharma, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Nupur Anand, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Disha Singh, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Ravi Dhawan, Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, Punjab, India

Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, Punjab, India

Md. Rageeb Md. Usman, Department of Pharmacognosy, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Department of Pharmacognosy, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Navneet Nagpal, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India

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1.
Nagpal MA, Sharma K, Anand N, Singh D, Dhawan R, Usman MRM, Nagpal N. Preparation and Evaluation of Sulfacetamide Sodium Ocusert for Controlled Drug Delivery. JDDT [Internet]. 15Mar.2020 [cited 9Apr.2020];10(2):164-70. Available from: http://jddtonline.info/index.php/jddt/article/view/3928