Solid Dispersion: Solubility Enhancement Technique of Poorly Water Soluble Drug

  • , Ikram Global Institute of Pharmacy Education and Research, Kashipur, Uttarakhand, India
  • Kapil Kumar Global Institute of Pharmacy Education and Research, Kashipur, Uttarakhand, India

Abstract

Solid dispersion is a technique which is widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. Dispersion of one or more active ingredients (hydrophobic) is done with an inert carrier (hydrophilic) at solid-state prepared by fusion method, solvent, and melting solvent method. In this review article, we have focused on the methods of preparation, advantages, disadvantages and characterization of the solid dispersions.


Keywords: Solid dispersion; dissolution; solubility.

Keywords: Solid dispersion, solubility, dissolution

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Author Biographies

, Ikram, Global Institute of Pharmacy Education and Research, Kashipur, Uttarakhand, India

Global Institute of Pharmacy Education and Research, Kashipur, Uttarakhand, India

Kapil Kumar, Global Institute of Pharmacy Education and Research, Kashipur, Uttarakhand, India

Global Institute of Pharmacy Education and Research, Kashipur, Uttarakhand, India

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Ikram , Kumar K. Solid Dispersion: Solubility Enhancement Technique of Poorly Water Soluble Drug. JDDT [Internet]. 14Mar.2020 [cited 26Jan.2022];10(1):173-7. Available from: http://jddtonline.info/index.php/jddt/article/view/3925