Formulation development and in-vitro evaluation of Molsidomine matrix tablets for colon specific release

  • D. Hema Naga Durga AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162
  • T. Lakshmi Sowjanya AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162
  • T. Pavani AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162
  • Lohithasu Duppala Division of Pharmaceutical Technology, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam (D), A.P-530003

Abstract

Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as coating polymers. FT-IR studies were carried out to find out the possible interaction between the selected drugs and polymer. FT-IR studies revealed that there  was  no  interaction between the selected drug and excipients. The pre-compression blend of all formulations was subjected to various flow property tests and all the formulations passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets passed all the tests. Among all the formulations F3 formulation was found to be optimized as it was retarded the drug release up to 12 hours and showed maximum of 97.57% drug release. It followed zero order kinetics mechanism. The ideal formulation was subjected to stability studies at 40°C/75%RH. The stability studies indicated that the formulation was stable and retained its pharmaceutical properties at 40°C/75%RH over a period of 1 month.


Keywords: Colon target, Ethyl cellulose, Eudragit L100 and S100, pH dependent polymers.

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Author Biographies

D. Hema Naga Durga, AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162

AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162

T. Lakshmi Sowjanya, AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162

AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162

T. Pavani, AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162

AVANTHI Institute of Pharmaceutical Sciences, Cherukupally (V), Bhogapuram (M), Vizianagaram (D), A.P-531162

Lohithasu Duppala, Division of Pharmaceutical Technology, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam (D), A.P-530003

Division of Pharmaceutical Technology, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam (D), A.P-530003

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Naga Durga DH, Sowjanya TL, Pavani T, Duppala L. Formulation development and in-vitro evaluation of Molsidomine matrix tablets for colon specific release. JDDT [Internet]. 15Mar.2020 [cited 9Apr.2020];10(2):59-8. Available from: http://jddtonline.info/index.php/jddt/article/view/3900