Preparation and assessment of ocular inserts containing sulbactum for controlled drug delivery

assessment of ocular inserts containing sulbactum

  • Monika Dhaka Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India
  • Rupa Mazumdar Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India
  • Md Rafiul Haque Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

Abstract

Ocuserts or Ophthalmic inserts are sterile preparations containing drug as dispersion or as solution in the polymeric support. The sulbactum is highly used as antibacterial agent in combination with other antibacterial agent. This study aims to formulate novel sulbactum ocuserts to enhance patient compliance through providing controlled drugs release from polymeric matrix. Ocuserts were prepared by solvent-casting method using different polymers HPMC, K4M, Polyvinyl alcohol,ethyl cellulose as polymer gelatine and propylene glycol and dibutyl phthalate as plasticizer in different ratios. The prepared ocusters were physic-chemichally evaluated for their weight, thickness, drug content uniformity, surface pH, swelling index (SI) and folding endurance. The viscosity of the polymeric solution used for the formulations was determined using Brookfield viscometer. In-Vitro Drug Release study and Accelerated stability studies were also performed. The prepared ocuserts show uniform weight, thickness and drug content. Their surface pH was in the physiological range and showed acceptable folding endurance. HPMC formulas had higher SI values. Results of in-vitro testing for one of the prepared ocuserts shows slow release of drugs up to 24 hours. One of the prepared ocuserts is promising for once-daily effective and safe drug delivery system of sulbactum for glaucoma treatment.


Keyword: Ocuserts, sulbactum, viscosity, Ophthalmic

Keywords: Ocuserts, sulbactum, viscosity

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Author Biographies

Monika Dhaka, Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

Rupa Mazumdar, Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

Md Rafiul Haque, Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

Noida Institute of Engineering & Technology, Greater Noida, 201306, Uttar Pradesh, India

References

1. Pandit JK, Bharathi D, Srinatha A, Ridhurkar DN and Singh S. Long acting ophthalmic formulation of indomethacin: Evaluation of alginate gel systems. Indian J Pharm Sci 2007; 69(1):37-40.
2. Srividya B, Cardoza RM and Amin PD. Sustained ophthalmic delivery of ofloxacin from pH triggered in situ gelling system. J Controlled Release. 2001; 73(2-3):205-11.
3. Bharath S. Sustained ophthalmic delivery of ofloxacin from an ionactivated in situ gelling system. Pak J Pharm.2009; 22(2):175-9.
4. Weisan P, ZhidongL, Jiawei L, Shufang N, Hui L and Pingtian D. Study of analginate/HPMC based in situ gelling ophthalmic delivery system for atifloxacin. Int J Pharm. 2006; 315:12-17.
5. Shapiro AB, Gao N, Jahic H, Carter NM, Chen A, Miller AA. Reversibility of covalent, broad-spectrum serine -lactamase inhibition by the diazabicyclooctenone ETX2514. ACS Infect Dis. 2017 3:833– 844.
6. Adnan S, Paterson DL, Lipman J, Roberts JA. Ampicillin/sulbactam: its potential use in treating infections in critically ill patients. Int J Antimicrob Agents. 2013; 42(5):384–9.
7. Penwell WF, Shapiro AB, Giacobbe RA, Gu RF, Gao N, Thresher J, et al. Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii. Antimicrob Agents Chemother. 2015; 59(3):1680–9.
8. Noguchi JK, Gill MA. Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988; 7(1):37–51.
9. Maria Gerald Rajan NS; Jayaprakash S, Somnath S. Design And Evaluation Of Polymeric Ocular Drug Delivery System For Controlled Release Of Tetracycline HCl. Ind J Pharm Sci. 2017; 63(6):526-528.
10. Di Colo G; Burgalassi S; Chetoni P; Fiaschi MP; Zambito Y, Saettone MF. Gel-forming erodible inserts for ocular controlled delivery of ofloxacin. Int J Pharm. 2001; 215:101- 111.
11. Srividya B; Rita M; Cardoza, PD Amin. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. J Control Rel. 2001; 73:205-211.
12. Lang JC. Ocular drug delivery conventional ocular formulations. Adv. Drug Deliv Rev. 1995; 16:39-43.
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Dhaka M, Mazumdar R, Haque MR. Preparation and assessment of ocular inserts containing sulbactum for controlled drug delivery. JDDT [Internet]. 15Feb.2020 [cited 27Feb.2020];10(1-s):66-1. Available from: http://jddtonline.info/index.php/jddt/article/view/3889