A Comparative Study of Analgesic, Antidiarrhoeal and Antimicrobial Activities of Methanol and Acetone Extracts of Fruits Peels of Limonia acidissima L. (Rutaceae)

  • Fahadul Islam Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • A.K. Azad Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Md. Faysal Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Md. A.K. Azad Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Saiful Islam Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Md. Al Amin Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Nahida Sultana Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Farhana Yeasmen Dola Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Md. Mominur Rahman Department of pharmacy, Daffodil International University, Dhaka, Bangladesh
  • Md. Zamshed Alam Begh Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Abstract

Objectives: Present study was designed to evaluate Analgesic, Antidiarrhoeal and Antimicrobial activities of methanol and acetone extracts of fruit peels of Limonia acidissima L. by different methods.


Method: The analgesic activity of the samples was studied using acetic acid- induced writhing model in mice. Castor oil-induced antidiarrheal activity was observed by Thomas method and antimicrobial activity was monitored by disc diffusion method.


Results: Limonia acidissima L. inhibited 60.53 % and 59.65 % writhing of methanol as well as acetone fruit peels extracts, respectively, compared to standard drug Diclofenac Na inhibited 78.07 % writhing. At higher dose (500 mg/kg) of the methanol and acetone fruit peels extracts, significant inhibition 47.13 and 44.83 % of characteristic diarrhoeal feces was observed, respectively, as well as at lower dose (250 mg/kg) of the both extracts, inhibition 34.45 and35.63 %. Mention able on average 12mm zone of inhibition was observed of both extract at 250µg/disc and 500µg/disc compare to zone of inhibition 36mm of ciprofloxacin at 50µg/disc.


Conclusion: From the above results, it will be very much possible source for an isolating lead compound for curing the numerous disorders.


Keywords: Limonia acidissima L. Fruit peels, Diclofenac sodium, Loperamide, Ciprofloxacin.

Keywords: Limonia acidissima L. Fruit peels, Diclofenac sodium, Loperamide, Ciprofloxacin

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Author Biographies

Fahadul Islam, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Research Associate, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

A.K. Azad, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Md. Faysal, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Md. A.K. Azad, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Saiful Islam, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Md. Al Amin, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Nahida Sultana, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Farhana Yeasmen Dola, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Md. Mominur Rahman, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Md. Zamshed Alam Begh, Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

Department of pharmacy, Daffodil International University, Dhaka, Bangladesh

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Islam F, Azad A, Faysal M, Azad MA, Islam S, Amin MA, Sultana N, Dola FY, Rahman MM, Begh MZA. A Comparative Study of Analgesic, Antidiarrhoeal and Antimicrobial Activities of Methanol and Acetone Extracts of Fruits Peels of Limonia acidissima L. (Rutaceae). JDDT [Internet]. 15Feb.2020 [cited 27Feb.2020];10(1-s):62-5. Available from: http://jddtonline.info/index.php/jddt/article/view/3882