Antidyslipidaemic and cardioprotective effects of turmeric (Curcuma longa) in rat fed a high cholesterol diet

  • Ikenna Kingsley Uchendu Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria
  • Ifeoma Blessing Ekeigwe Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria
  • Ebuka Bitrus Nnedu Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

Abstract

Objective: The aim of this study is to evaluate the antidyslipidaemic and cardioprotective effects of aqueous extract of Curcuma longa (AECL) in rats fed a high cholesterol diet (HCD).


Methods: Twenty (20) rats were randomly grouped into four groups: A-D of five animals per group. Groups A-C received HCD (2000mg/kg, oral) and carbimazole (60mg/kg, oral) daily for eight weeks. Group A served as negative control. Group B (positive control) was treated with atorvastatin (20mg/kg), while group C served as treatment group and received AECL (400mg/kg) daily for eight weeks. Group D served as normal control and received no treatment. After the administration, biochemical markers of Lipid profiles (total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C)) were assayed using standard methods. The hearts of the rats were harvested for histopathological studies.


Results: AECL significantly induced hypolipidaemia and stabilized lipid biochemical markers (p<0.05 or p<0.01); and protected the cardiac muscle fibres from injuries.


Conclusion: Tumeric (Curcuma longa) has antidyslipidaemic and cardioprotective effects.


Keywords: antidyslipidaemia, cardioprotection, Curcuma longa, ethnopharmacology, hypercholesterolaemia, Medicinal foods, cardiomyopathy

Keywords: antidyslipidaemia, cardiomyopathy, cardioprotection, Curcuma longa, ethnopharmacology, hypercholesterolaemia

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Author Biographies

Ikenna Kingsley Uchendu, Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

Ifeoma Blessing Ekeigwe, Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

Ebuka Bitrus Nnedu, Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria

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1.
Uchendu IK, Ekeigwe IB, Nnedu EB. Antidyslipidaemic and cardioprotective effects of turmeric (Curcuma longa) in rat fed a high cholesterol diet. JDDT [Internet]. 15Feb.2020 [cited 27Feb.2020];10(1-s):178-81. Available from: http://jddtonline.info/index.php/jddt/article/view/3869