Therapeutic Considerations for Docetaxel and Paclitaxel in Metastatic Breast Cancer

  • Doranala Harshini Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India
  • Sreenivas Pasula Assistant Professor, Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India
  • Vesangi Keerthi Vaishnavi Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India
  • Shiva Sai Tekula Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India
  • M. Rajendar Department of Pharmacology Bhaskar Pharmacy College, Moinabad, Hyderabad, India
  • A. Srinivas Rao Department of Pharmacology Bhaskar Pharmacy College, Moinabad, Hyderabad, India
  • A.V. Kishore Babu Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Abstract

Breast cancer is the main source of death among women. Currently, 77% of women diagnosed with breast cancer are age 50 and older; however, it is projected that approximately 66% of the new cases diagnosed will occur in women younger than 65. Several clinical trials have assessed the wellbeing and adequacy of taxanes along with their tolerability in patients with metastatic cancer (MBC) The overview of these Paclitaxel and Docetaxel, the mechanism of action, pharmacokinetics and pharmacodynamics, dose and administration, adverse effects, clinical potency, and sufferable profiles combination therapies, the pathological complete response of these taxanes are included. The different novel formulations of taxanes are formulated from nanoparticles, polyglutamate, liposomes to improve the wellbeing and adequacy taxanes to reduce their toxicities. Single-agent research located with docetaxel and paclitaxel in metastatic breast most cancers show clinically huge antitumor motion even in the advanced stage, heavily pretreated, safe, as properly as in refractory diseases. This action is likewise clear with taxane-based combination regimens. Serious hematologic and nonhematologic toxicities are incompatible, with different toxicities noted dependent on the portion and weekly regimen selected.  Weekly docetaxel and paclitaxel regimens speak to important helpful treatment options for women suffering from metastatic breast cancer and have entered assessment as a major aspect of adjuvant treatment for this disease Toxicity associated with taxanes chemotherapy are based totally on the dose schedules and weekly regimen selected and the most frequent toxicities related with these marketers include myalgia, peripheral neuropathy, neutropenia, etc Docetaxel retains in tumor cells for longer duration when compared to paclitaxel because of its slow efflux and large amounts of uptake into the cell which explains its more benefits when compared to paclitaxel. Clinical studies conducted so far suggested a more benefit to risk ratio for docetaxel when compared to paclitaxel. This article reviews mainly different actions exhibited by taxanes in the therapy of metastatic breast cancer and others on stages of cancer along with the toxicities associated with these agents.


 

Keywords: Metastatic breast cancer, Taxanes, Paclitaxel, Docetaxel

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Author Biographies

Doranala Harshini, Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Sreenivas Pasula, Assistant Professor, Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Assistant Professor, Department of Pharmacy  Practice,  Bhaskar Pharmacy  College,  Moinabad,  Hyderabad,  India

Vesangi Keerthi Vaishnavi, Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Shiva Sai Tekula, Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

M. Rajendar, Department of Pharmacology Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Department of Pharmacology Bhaskar Pharmacy College, Moinabad, Hyderabad, India

A. Srinivas Rao, Department of Pharmacology Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Department of Pharmacology Bhaskar Pharmacy College, Moinabad, Hyderabad, India

A.V. Kishore Babu, Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

Pharm D Department of Pharmacy Practice, Bhaskar Pharmacy College, Moinabad, Hyderabad, India

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Harshini D, Pasula S, Vaishnavi VK, Tekula SS, Rajendar M, Srinivas Rao A, Kishore Babu A. Therapeutic Considerations for Docetaxel and Paclitaxel in Metastatic Breast Cancer. JDDT [Internet]. 15Feb.2020 [cited 27Feb.2020];10(1-s):196-04. Available from: http://jddtonline.info/index.php/jddt/article/view/3852