Ligand Decorated Embelin Loaded PLGA Nanoparticles for Management of Alcohol Induced Hepatotoxicity

  • Ajay Kumar Government Pharmacy Institute, Agamkuan, Patna, 800007, India
  • M. Nikhat Khan Department of Pharmaceutics, I.S.F. College of Pharmacy, GhalKalan, Ferozpur G.T. Road, Moga, Punjab, India; 142001
  • Jovita Kanoujia Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, India
  • Amandeep Singh Department of Pharmaceutics, I.S.F. College of Pharmacy, GhalKalan, Ferozpur G.T. Road, Moga, Punjab, India; 142001
  • Neeraj Mishra Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, India


Preparation of surface modified Embelin loaded nanoparticles (GA-PEG-PLGA) for the management of hepatotoxicity. Surface modified Embelin loaded GA-PEG-PLGA NPs were evaluated by NMR, FTIR, TEM techniques and in vitro release studies. The biodistribution of the nanoparticles was assessed by High-performance liquid chromatography (HPLC), and the cellular uptake study was evaluated using Hep G2 cells (liver cells lines). The hepatoprotecttive effect of the surface modified Embelin loaded GA-PEG-PLGA NPs was investigated in-vitro and in-vivo. The surface modified Embelin loaded GA-PEG-PLGA nanoparticles significantly increases the uptake of drug in liver by 2.5 folds more than plain drug.

Keywords: Glycyrrhetinic acid, Receptor mediated, Surface functionalization, Embelin, PLGA nanoparticle.


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Kumar A, Khan MN, Kanoujia J, Singh A, Mishra N. Ligand Decorated Embelin Loaded PLGA Nanoparticles for Management of Alcohol Induced Hepatotoxicity. JDDT [Internet]. 15Jan.2020 [cited 29Mar.2020];10(1):72-0. Available from: