Tirosyne Kinase Inhibithors (TKIs) in the Treatment of Non –Small Cell Lung Cancer (NSCLC), Practical Pharmacological Aspects

  • Alexandru C. Grigorescu The Oncological Institute of Bucharest, 252 Sos. Fundeni, Bucuresti, Romania
  • Laura Mihaela Teodorescu V. Babes Diagnostic and Treatment Center, 281 Sos M. Bravu, 143308 Bucharest, Romania

Abstract

Tyrosine Kinase Inhibitors are new drugs developed in the last decade. For Non-Small Cell Lung Cancer this drug brought more hope for patients with this disease. Also TKIs are better tolerated then chemotherapy. The efficacy of TKIs is dependent of the presence of Epidermal Grows Factor Receptor gene mutation. This mutation account for about 9% of patients with lung cancer in Europe. This short review try to give the minimal knowledge to clinicians, especially medical oncologists, about mechanism of action, pharmacokinetics of TKIs used in the treatment NSCLC.

Keywords: Tyrosine Kinase Inhibitors (TKI); Non -Small Cell Lung Cancer; Pharmacokinetics aspects

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Tyrosine Kinase Inhibitors are new drugs developed in the last decade. For Non-Small Cell Lung Cancer this drug brought more hope for patients with this disease. Also TKIs are better tolerated then chemotherapy. The efficacy of TKIs is dependent of the presence of Epidermal Grows Factor Receptor gene mutation. This mutation account for about 9% of patients with lung cancer in Europe. This short review try to give the minimal knowledge to clinicians, especially medical oncologists, about mechanism of action, pharmacokinetics of TKIs used in the treatment NSCLC.
Keywords: Tyrosine Kinase Inhibitors (TKI); Non -Small Cell Lung Cancer; Pharmacokinetics aspects
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Grigorescu, A. C., & Teodorescu, L. M. (2020). Tirosyne Kinase Inhibithors (TKIs) in the Treatment of Non –Small Cell Lung Cancer (NSCLC), Practical Pharmacological Aspects. Journal of Drug Delivery and Therapeutics, 10(1), 135-138. https://doi.org/10.22270/jddt.v10i1.3830