In-Vitro Comparative Dissolution Study of Commercially Available Paracetamol Tablet
Quality is the most important issue in the pharmaceutical field due to the presence of a drug which is considered as safe and therapeutically active agent. In-vitro evaluation ensures their quality, bioavailability as well as optimum therapeutic activity. Paracetamol (acetaminophen) which are the active metabolites of phenacetin is commonly used for the relief of headaches and pains, and is a major ingredient in numerous cold and flu remedies. Paracetamols are available in different brands in Indian market. The main objective of the present study was to conduct the comparative in-vitro dissolution studies of various brands collected from the local market to determine whether all the formulations used were equivalent or significantly different. The calibration curve was constructed covering the concentration range of 1 to 10 mcg/ml at 268 nm by UV spectrophotometer (UV 2203 Double beam spectrophotometer, Shimadzu). Five different brands of Paracetamol of 500 mg conventional tablets from different manufacturers were selected in the study and dissolution testing in Phosphate buffer at pH 7.4 was conducted from each brands for 90 mins by using dissolution testing apparatus USP type-II. The dissolution rate was subjected to various mathematical models like zero order, first order, Higuchi and Hixson-Crowell equations to elucidate the kinetic behavior of drug release from the test samples. Different release kinetics model of all the selected brands was assuring the quality standard of manufacturing.
Keywords: Paracetamol, Marketed Tablet, In-Vitro dissolution study, Release profile.
2. Sowjanya S P, Madhavi C H, Sowjanya D, Girisha D, Deeraj D, Vidya D S. Formulation and enhancement of dissolution rate of paracetamol tablets employing selected binders and disintegrants as per 22 factorial design. Indian Journal of Pharmaceutical Science & Research, 2016; 6(2): 73 -77.
3. Sultana R, Sarker K and Sultana S. Preparation and evaluation of paracetamol effervescent tablets under normal and exaggerated storage conditions. Bangladesh Pharmaceutical Journal, 2014; 17(1): 75 – 78.
4. Aulton M E. Aulton’s Pharmaceutics : The Design and manufacture of Medicines, 2nd edition, Churchill livingstone, 1987.
5. Ghayas S, Sheraz M A, Anjum F, Baig M T. Factors influencing the dissolution testing of drugs. Pakistan Journal of Health Research, 2013; 1(1): 1 – 11.
6. The Indian Pharmacopoeia, Government of India, Ministry of health and family welfare, Controller of publication, New delhi, vol. II, 1996, A80 – A84.
7. Ahmida N H S, Abu – Naja M S, Doghman Y S A. Determination of paracetamol in tablet by Different Spectrophotometric Method. Asian Journal of Chemistry, 2009; 21(3): 2233 – 2240.
8. Kumar C S P, Ratna J V, Aditya P, Raakhiya SK, Sunitha S V, Revathi S. Formulation and evaluation of fast dissolving tablets of paracetamol using oats powder. International Journal of Pharmaceutical Science Invention, 2016; 5(3):7 – 12.
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