Formulation and Evaluation of Etoricoxib Herbal Gel for Analgesic Activity
Abstract
Medicinal plants play an imperative function in the development of potent therapeutic agents. The existing study has been undertaken with the plan to formulate and evaluate the etoricoxib herbal gel containing Buchanania lanzan extract for the management and treatment of pain. The etoricoxib herbal gel formulation was intended by using etoricoxib, menthol, linseed oil with different polymers and additives in the composition of gel. Formulated gel was evaluated in terms of various evaluation parameters as physicochemical assessment, pH, viscosity and spreadibility. Further, formulated etoricoxib herbal gel was investigated for analgesic activity by using hot-plate and acetic acid induced writhing methods. The obtained findings conclude that formulated etoricoxib herbal gel is the appropriate option for the treatment of pain and such other indications.
Keywords: Pain, Analgesic, Etoricoxib, Buchanania lanzan
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References
2. Fields HL, Martin JB. Pain, Pathophysiology and Management. In: Harrisons principles of internal medicine. 17th edition. New Delhi: McGraw-Hill, 2008; 1514-1526.
3. Choubey A. Some aspects of germination studies in Buchanania lanzan Spreng. seeds. Journal of Tropical Forestry 1997; 13 (11):65- 73.
4. Shukla SK, Solanki KR. Studies on seed germination, plant survival and growth of chironjee (Buchanania lanzan Spreng). Journal of Tropical Forestry 2000; 16:44-49.
5. Lalit K, Ruchi V. In vitro evaluation of topical gel prepared using natural polymer. International Journal of drug delivery 2010; 2:58-63.
6. Gupta R, Gupta GS. Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia oblique topical Gel on Animal Model. Pharmacognosy Journal 2017; 9 (6): 93-98.
7. Basha BN, Prakasam K, Goli D. Formulation and evaluation of gel containing the fluconazole-antifungal agent. International Journal of Drug Development Research 2011; 3:109-28.
8. Eddy NB, Leimback D. Synthetic analgesic. II. Dithienyl butenylanddithienyl butyl amines. Journal of Pharmacology Experimental Therapy 1953; 107: 385-393.
9. Suseem SR, Mary S, Reddy N, Gregory M. Evaluation of the analgesic activity of ethyl acetate, methanol and aqueous extracts of Pleurotuseous mushroom. Asian Pacific Journal of Tropical Medicine 2011; 4 (2):117- 120.
10. Koster R, Anderson M, De Beer EJ. Acetic acid for analgesics screening. Federation Proceeding. 1959; 18: 412–417.
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