Current Approaches on Gastroretentive Drug Delivery systems

  • Aniket Uttam Pund Research scholar, Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India
  • Raosaheb Sopanrao Shendge Professor, Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India
  • Ajinkya Kailas Pote Research scholar, Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon,Maharashtra, India


Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action.

Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.


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Pund A, Shendge R, Pote A. Current Approaches on Gastroretentive Drug Delivery systems. JDDT [Internet]. 15Jan.2020 [cited 18Jan.2021];10(1):139-46. Available from: