ANTI-INFLAMMATORY ACTIVITY OF ROOT OF DECALEPSIS HAMILTONII

  • Mohua* Sengupta* Medical College,Kolkata West Bengal University of Health Sciences.
  • Ashim Kumar Ghosh Medical College, Kolkata. WBUHS
  • Indrani Dalal Department of Pharmacology. WBUHS.
  • suhrita Paul Department of Pharmacology. WBUHS.

Abstract

Powdered root of Decalepsis hamiltonii was used to evaluate the acute & chronic anti-inflammatory activities in rodents. Albino rats of either sex were divided into 4 sets (n=24). Set A, B, C was used for evaluating the anti inflammatory activity after inducing acute inflammation with carrageenan, bradykinin and 5HT respectively while Set D was used for evaluating the anti inflammatory activity after inducing chronic inflammation with formaldehyde. Each set was subdivided into four groups I-IV (n=6). In all the sets, GR I served as control (receiving gum acacia only), GR II received root extract of D. hamiltonii at the dose of 250mg /kg, GR III received Phenylbutazone 50 mg / Kg, and GR IV received Dexamethasone 0.5 mg / Kg. There was inflammatory inhibition of 35.55% in carrageenan induced, 42.62% in 5HT induced and 36.62% in bradykinin induced acute inflammatory models. In the chronic Inflammatory model, a progressive inhibition of 36.84% (3rd day), 36.45% (5th day), 51.45% (7th day) and 66.39% (13th day) was observed with study compound. The efficacy was comparable to the standard drugs. To summarize, we can say that Decalepsis hamiltonii is an anti-inflammatory and anti arthritic agent that may block histamine and serotonin path way. It may be an effective alternative to NSAIDs and corticosteroids in inflammatory disorders.

KeyWord:Antiinflammatoryactivities,D.hamiltonii, rodents


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Author Biographies

Mohua* Sengupta*, Medical College,Kolkata West Bengal University of Health Sciences.

Assistant Professor.

Department of Pharmacology.

Ashim Kumar Ghosh, Medical College, Kolkata. WBUHS

Professor,

Department of Pharmacology.

 

Indrani Dalal, Department of Pharmacology. WBUHS.

Assistant Professor,

Department of Pharmacology.

suhrita Paul, Department of Pharmacology. WBUHS.
Professor,
Department of Pharmacology.
WBUHS
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How to Cite
Sengupta*, M., Ghosh, A., Dalal, I., & Paul, suhrita. (2013). ANTI-INFLAMMATORY ACTIVITY OF ROOT OF DECALEPSIS HAMILTONII. Journal of Drug Delivery and Therapeutics, 3(1). https://doi.org/10.22270/jddt.v3i1.379