Evolocumab in treatment of acute pancreatitis induced by hypertriglyceridemia

  • Kamel El-Reshaid Department of Medicine, Faculty of Medicine, Kuwait University, P O Box 24923, 13110 Safat, Kuwait
  • Shaikha Al-Bader Department of Medicine, Nephrology unit, Amiri hospital, Ministry of health, Kuwait
  • Zhaneta Markova Department of Radiology, IMC, Kuwait

Abstract

Acute pancreatitis (AP) is a common emergency resulting from inflammation of the pancreas. The mechanism involves premature activation of enzyme precursors in the acinar cells triggering a self-digestive inflammatory cascade.  Hypertriglyceridemia is the most common etiology of pancreatitis after gall stones and alcohol.  It usually follows a sudden surge such as diabetic ketoacidosis on top of hereditary hyperlipidemia.  In the present case report; we describe a patient with type-I diabetes mellitus who had developed recurrent attacks of hypertriglyceridemia AP (HTG-AP) despite Fenfibrate-therapy and report on our experience with Evolocumab in his treatment and prophylaxis. 


Keywords: diabetes mellitus, hypertriglyceridemia, pancreatitis, prophylaxis, treatment.

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How to Cite
El-Reshaid, K., Al-Bader, S., & Markova, Z. (2019). Evolocumab in treatment of acute pancreatitis induced by hypertriglyceridemia. Journal of Drug Delivery and Therapeutics, 9(6), 136-139. https://doi.org/10.22270/jddt.v9i6.3717