Formulation and Evaluation of Orodispersible Tablet of Atorvastatin Calcium by Using Hibiscus rosa sinesis Mucilage as Natural Superdisintegrant

  • Ashish Gupta Acropolis Institute of Pharmaceutical Education and Research, Indore, Indore Dewas Bypass Road,Manglia Square, Indore (M.P.) 453771
  • Juhi Bhadoria Acropolis Institute of Pharmaceutical Education and Research, Indore, Indore Dewas Bypass Road,Manglia Square, Indore (M.P.) 453771
  • G.N. Darwhekar Acropolis Institute of Pharmaceutical Education and Research, Indore, Indore Dewas Bypass Road,Manglia Square, Indore (M.P.) 453771

Abstract

Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. Oral bioavailability of Atorvastatin Calcium is low (14%) and shows extensive intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability. In the present work, orodispersible tablets of Atorvastatin calcium were prepared by direct compression method using Hibiscus rosa sinesis mucilage as natural superdisintegrant with a view to enhance patient compliance and to avoid hepatic first pass metabolism and to improve its bioavailability. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water-absorption ratio and in-vitro dispersion time. Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dispersion time.


Keywords: Orodispersible tablet, Atorvastatin Calcium, lipid-lowering agent, Superdisintegrant, Hibiscus Rosa Sinensis, Bioavailability, solubility. 

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References

1. Gauri S, Kumar G. Fast Dissolving Drug Delivery and its Technologies. The Pharma Innovation, 2012; 1(2):34-39.
2. Mudgal, V. K., Sethi P., Kheri R., Saraogi G.K., Singhai A.K. Orally Disintegrating Tablets: A Review. International Research Journal of Pharmacy, 2011; 2(4):16 -22.
3. Mehta K., Garala K., Basu B., Bhalodia R., Joshi B., Charyulu N. An Emerging Trend in Oral Drug Delivery Technology: Rapid Disintegrating Tablets. Journal of Pharmaceutical Science and Technology, 2010; 2(10):318-329.
4. Shihora H., Panda S. Superdisintegrants, utility in Dosage Forms: A Quick Review. Journal of Pharmaceutical Science and Biosientipic Resarch, 2011; 1(3):148-153.
5. Sharma V., Arora V., Ray C. Use of Natural superdisintegrant in Mouth Dissolving Tablet an Emerging Trend. International Bulletin of Drug Research, 2010; 1(2):46-54.
6. Bala R., *Madaan R., Vibhu A. And Dr. Arora S. Isolation and Evaluation Of Hibiscus Rosa- Sinensis Leaf Mucilage As Superdisintegrant. European Journal of Pharmaceutical and Medical Research. ejpmr, 2016; 3(8):434-440
7. Carrier R.L., Miller L.A., Ahmed I. The utility of cyclodextrins for enhancing oral bioavailability. J Control Release, 2007; 123:78e99.
8. Singh A., Worku Z.A., Van den Mooter G. Oral formulation strategies to improve solubility of poorly water-soluble drugs Expert Opin Drug Delivery, 2011; 8:1361-1378.
9. Rowe R.C., Sheskey P.J. and Quinn M.E. Handbook of Pharmaceutical Excipients Sixth edition published. Published by the Pharmaceutical Press, 2009; 404-407.
10. Jadhav N.R., Kambar R.S. and Nadaf S.J. Research Article Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form Hindawi Publishing Corporation Advances in Chemistry Volume, Article ID, 2014; 131974, 6.
11. Rao K.S. Enhancement of dissolution rate and bioavailability of Aceclofenac by Complexation with cyclodextrin Research Journal of Pharmaceutical and Chemical Science Oct-Dec, 2010; 1(4):142-152.
12. Stability testing of new drug substances and products, ICH Guidelines, 6 February 2003, Available at:
https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q1A_R2/Step4/Q1A_R2_Guideline.pdf.
13. Umekar M.J. Formulation and Characterization of lornoxicam fast dissolving tablet using natural superdisintegrants, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2013; 2:459-64.
14. Goyani S.M., Shah P. Formulation and evaluation of orally disintegrating tablets of meclizine hydrochloride Int. Res. J. Pharm, 2012; 3(3):196-99.
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Gupta, A., Bhadoria, J., & Darwhekar, G. (2019). Formulation and Evaluation of Orodispersible Tablet of Atorvastatin Calcium by Using Hibiscus rosa sinesis Mucilage as Natural Superdisintegrant. Journal of Drug Delivery and Therapeutics, 9(6), 90-94. https://doi.org/10.22270/jddt.v9i6.3677